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Ihsan Gursel
Researcher at Bilkent University
Publications - 109
Citations - 9525
Ihsan Gursel is an academic researcher from Bilkent University. The author has contributed to research in topics: Immune system & CpG Oligodeoxynucleotide. The author has an hindex of 39, co-authored 103 publications receiving 7863 citations. Previous affiliations of Ihsan Gursel include University of London & Middle East Technical University.
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Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
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Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells
Fumihiko Takeshita,Cynthia A. Leifer,Ihsan Gursel,Ken Ishii,Saoko Takeshita,Mayda Gursel,Dennis M. Klinman +6 more
TL;DR: Findings indicate that hTLR9 plays a critical role in the CpG DNA-mediated activation of human cells and evolutionary divergence between TLR9 molecules underlies species-specific differences in the recognition of bacterial DNA.
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Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
Stefano Fais,Lorraine O'Driscoll,Francesc E. Borràs,Edit I. Buzás,Giovanni Camussi,Francesco Cappello,Joana Carvalho,Anabela Cordeiro da Silva,Hernando A. del Portillo,Samir El Andaloussi,Samir El Andaloussi,Tanja Ficko Trček,Roberto Furlan,An Hendrix,Ihsan Gursel,Veronika Kralj-Iglič,Bertrand Kaeffer,Maja Kosanović,Marilena E. Lekka,Georg Lipps,Mariantonia Logozzi,Antonio Marcilla,Marei Sammar,Alicia Llorente,Irina Nazarenko,Carla Oliveira,Gabriella Pocsfalvi,Lawrence Rajendran,Graça Raposo,Eva Rohde,Pia Siljander,Guillaume van Niel,M. Helena Vasconcelos,María Yáñez-Mó,Marjo Yliperttula,Natasa Zarovni,Apolonija Bedina Zavec,Bernd Giebel +37 more
TL;DR: The high potential of nanosized EVs for both diagnostic and therapeutic areas of nanomedicine, as demonstrated by the European Network on Microvesicles and Exosomes in Health and Disease (ME-HAD), is demonstrated.
Journal ArticleDOI
Use of CpG oligodeoxynucleotides as immune adjuvants
TL;DR: Synthetic oligodeoxynucleotides containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells, thereby promoting the production of T helper 1 and pro‐inflammatory cytokines and the maturation/activation of professional antigen‐presenting cells.
Journal ArticleDOI
Efficient production and enhanced tumor delivery of engineered extracellular vesicles.
Dionysios C. Watson,Defne Bayik,Avinash Srivatsan,Cristina Bergamaschi,Antonio Valentin,Gang Niu,Jenifer Bear,Mitchell K. Monninger,Mei Sun,Aizea Morales-Kastresana,Jennifer Jones,Barbara K. Felber,Xiaoyuan Chen,Ihsan Gursel,George N. Pavlakis +14 more
TL;DR: The Scavenger Receptor Class A family (SR-A) is identified as a novel monocyte/macrophage uptake receptor for EV and blockade of SR-A with dextran sulfate dramatically decreased EV liver clearance in mice, while enhancing tumor accumulation.