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Iichiro Shimomura
Researcher at Osaka University
Publications - 607
Citations - 48598
Iichiro Shimomura is an academic researcher from Osaka University. The author has contributed to research in topics: Diabetes mellitus & Adiponectin. The author has an hindex of 82, co-authored 554 publications receiving 44160 citations. Previous affiliations of Iichiro Shimomura include National Presto Industries.
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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
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Increased oxidative stress in obesity and its impact on metabolic syndrome
Shigetada Furukawa,Takuya Fujita,Michio Shimabukuro,Masanori Iwaki,Yukio Yamada,Yoshimitsu Nakajima,Osamu Nakayama,Makoto Makishima,Morihiro Matsuda,Iichiro Shimomura +9 more
TL;DR: It is suggested that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
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cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).
Kazuhisa Maeda,Kousaku Okubo,Iichiro Shimomura,Tohru Funahashi,Yuji Matsuzawa,Kenichi Matsubara +5 more
TL;DR: The apM1 gene encodes a 244 amino acid open reading frame containing a putative signal sequence and G-X-Y repeats (66 amino acids) followed by a cluster of aromatic residues near the C terminus having high local similarity with collagens X and VIII and complement factor C1q.
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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Norikazu Maeda,Iichiro Shimomura,Ken Kishida,Hitoshi Nishizawa,Morihiro Matsuda,Hiroyuki Nagaretani,Naoki Furuyama,Hidehiko Kondo,Masahiko Takahashi,Yukio Arita,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Yoshihiro Tochino,Keiichi Okutomi,Masato Horie,Satoshi Takeda,Toshifumi Aoyama,Tohru Funahashi,Yuji Matsuzawa +19 more
TL;DR: The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
Journal ArticleDOI
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Atsunori Fukuhara,Morihiro Matsuda,Masako Nishizawa,Katsumori Segawa,Masaki Tanaka,Kae Kishimoto,Yasushi Matsuki,Mirei Murakami,Tomoko Ichisaka,Hiroko Murakami,Eijiro Watanabe,Toshiyuki Takagi,Megumi Akiyoshi,Tsuguteru Ohtsubo,Shinji Kihara,Shizuya Yamashita,Makoto Makishima,Tohru Funahashi,Shinya Yamanaka,Ryuji Hiramatsu,Yuji Matsuzawa,Iichiro Shimomura,Iichiro Shimomura +22 more
TL;DR: A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated.