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Ika Kristiana
Researcher at University of New South Wales
Publications - 17
Citations - 900
Ika Kristiana is an academic researcher from University of New South Wales. The author has contributed to research in topics: Cholesterol & HMG-CoA reductase. The author has an hindex of 11, co-authored 17 publications receiving 786 citations.
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Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase
TL;DR: It is found that cholesterol caused the accumulation of the substrate squalene, suggesting that SM may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting) and suggesting this as a possible control point in cholesterol synthesis.
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Involvement of Akt in ER-to-Golgi Transport of SCAP/SREBP: A Link between a Key Cell Proliferative Pathway and Membrane Synthesis
TL;DR: Results provide a crucial mechanistic link between the SREBP and PI3K/Akt pathways that may be reconciled teleologically because synthesis of new membrane is an absolute requirement for cell growth and proliferation.
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The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway
Noam Zelcer,Laura J. Sharpe,Anke Loregger,Ika Kristiana,Emma C. L. Cook,Lisa Phan,Julian Stevenson,Andrew J. Brown +7 more
TL;DR: It is found that knockdown of MARCH6 controls abundance of both SM and HMGCR, establishing it as a major regulator of flux through the cholesterol synthesis pathway.
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The molecular basis of urgency: regional difference of vanilloid receptor expression in the human urinary bladder.
TL;DR: The hypothesis that there would be an upregulation of TRPV1 in mucosa of patients with bladder hypersensitivity but not idiopathic detrusor overactivity (IDO) is tested.
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Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol.
TL;DR: It is determined that APDs disrupt intracellular trafficking and synthesis of cholesterol, which may have important clinical ramifications, as has been shown for other amphiphiles.