I
Ildar Gainetdinov
Researcher at University of Massachusetts Medical School
Publications - 33
Citations - 1586
Ildar Gainetdinov is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Piwi-interacting RNA & Argonaute. The author has an hindex of 13, co-authored 27 publications receiving 872 citations. Previous affiliations of Ildar Gainetdinov include Howard Hughes Medical Institute & Russian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
PIWI-interacting RNAs: small RNAs with big functions
TL;DR: The authors describe the latest understanding of piRNA biogenesis and functions across diverse species, highlighting how, despite the universal importance of transposon control, different species have evolved intriguingly distinct mechanistic routes to achieve this.
Journal ArticleDOI
A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing
Alireza Edraki,Aamir Mir,Raed Ibraheim,Ildar Gainetdinov,Yeonsoo Yoon,Chun-Qing Song,Yueying Cao,Judith Gallant,Wen Xue,Jaime A. Rivera-Pérez,Erik J. Sontheimer +10 more
TL;DR: Nme2Cas9 combines all-in-one AAV compatibility, exceptional editing accuracy within cells, and high target site density for in-vivo genome editing applications and expands the single-AAV platform to pre-implanted zygotes for streamlined generation of genome-edited mice.
Journal ArticleDOI
A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals.
TL;DR: The unified model places PIWI-clade Argonautes at the center of piRNA biology and suggests that the ancestral animal-the Urmetazoan-used PIWI proteins both to generate piRNA guides and to execute piRNA function.
Journal ArticleDOI
The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility
Pei Hsuan Wu,Yu Fu,Yu Fu,Yu Fu,Katharine Cecchini,Deniz M. Ozata,Amena Arif,Tianxiong Yu,Tianxiong Yu,Cansu Colpan,Ildar Gainetdinov,Zhiping Weng,Phillip D. Zamore +12 more
TL;DR: It is reported that males lacking piRNAs from a conserved mouse pachytene piRNA locus on chromosome 6 (pi6) produce sperm with defects in capacitation and egg fertilization, and heterozygous embryos sired by pi6−/− fathers show reduced viability in utero.
Journal ArticleDOI
Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.
Jooyoung Lee,Aamir Mir,Alireza Edraki,Bianca Garcia,Nadia Amrani,Hannah E. Lou,Ildar Gainetdinov,April Pawluk,Raed Ibraheim,Xin D. Gao,Pengpeng Liu,Alan R. Davidson,Karen L. Maxwell,Erik J. Sontheimer +13 more
TL;DR: Two new type II-C anti-CRISPRs and their cognate Cas9 orthologs are identified and their functionality in vitro and in bacteria are validated, their inhibitory spectrum is defined, and their utility as off-switches for Cas9-based tools in mammalian applications is documented.