Ilka Diester

TL;DR: An ImageJ plugin is presented that enables non-machine-learning experts to analyze their data with U-Net on either a local computer or a remote server/cloud service.

TL;DR: Subcellular and transcellular trafficking strategies now permit increased potency of optical inhibition without increased light power requirement, and generalizable strategies for targeting cells based not only on genetic identity, but also on morphology and tissue topology, to allow versatile targeting when promoters are not known or in genetically intractable organisms.

TL;DR: These neurons could be activated by cocaine, and silencing this drug-induced activity during cocaine exposure (despite the fact that the manipulation of the cholinergic interneurons was not aversive by itself) blocked cocaine conditioning in freely moving mammals.

TL;DR: A new device for measuring in vivo fluorescence over time, allowing minimally invasive assessment of construct expression in the intact brain and a set of optogenetic tools designed for optogenetics experiments in the non-human primate brain are presented.

TL;DR: A flexible and modular approach is used to target intersectionally specified populations of inhibitory interneurons in mammalian hippocampus and neurons of the ventral tegmental area defined by both genetic and wiring properties, which may expand the application of genetically encoded interventional and observational tools for intact-systems biology.