Ilpo Vattulainen

TL;DR: The detailed lipid composition provided in this study may be useful to understand the mechanism of exosome formation, release and function, and several of the lipids enriched in exosomes could potentially be used as cancer biomarkers.

TL;DR: The biophysical effects of cholesterol on the lipid bilayer are discussed, in particular the ordering and condensing effects, concentrating on the molecular level or inter-atomic interactions perspective, starting from two-component systems and proceeding to many-component ones e.g., modeling lipid rafts.

TL;DR: Pronounced maxima or minima in g(r) appear exactly at the cutoff distance indicating that the truncation gives rise to artificial ordering between the polar phosphatidyl and choline groups of the DPPC molecules, whereas in systems described using PME, such artificial ordering is not present.

TL;DR: The coarse-grained Martini force field is widely used in biomolecular simulations as discussed by the authors, which allows accurate predictions of molecular packing and interactions in general, exemplified with a vast and diverse set of applications, ranging from oil/water partitioning and miscibility data to complex molecular systems, involving protein-protein and protein-lipid interactions and material science applications as ionic liquids and aedamers.

TL;DR: In this article, the effects of short-chain alcohols, methanol and ethanol, on two different fully hydrated lipid bilayer systems (POPC and DPPC) in the fluid phase at 323 K were investigated.