In-Sook Kwun

TL;DR: The study results imply that zinc can increase osteogenic effect by stimulating cell proliferation, ALP activity and collagen synthesis in osteoblastic cells.

TL;DR: Zhang et al. as discussed by the authors investigated whether zinc deficiency down-regulates bone marker gene transcription and whether this might occur through modulation of Runx2 and found that zinc deficiency decreased ECM mineralization in osteoblastic MC3T3-E1 cells.

TL;DR: Studies using appropriate animal models and investigating how the plasma Zn pool influences endothelial intracellular labile Zn would be helpful in appreciating the importance of Zn deficiency in atherogenesis.

TL;DR: The effects of commonly consumed polyphenols, including curcumin, epigallocatechin gallate and green tea extract, resveratrol, nobiletin and citrus fruits, pomegranate, as well as genistein and soy protein, on osteoarthritis are discussed with an emphasis on molecular antiosteoarthritic mechanisms.

TL;DR: Animal and cellular studies of dried plum and citrus and berry fruits and bioactive compounds including lycopene, phenolics, favonoids, resveratrol, phloridzin, and pectin derived from tomato, grapes, apples, and citrus fruits suggest that commonly consumed antioxidant-rich fruits have a pronounced effect on bone, as shown by higher bone mass, trabecular bone volume, number, and thickness.