scispace - formally typeset
Search or ask a question
Author

Inam Ullah

Bio: Inam Ullah is an academic researcher from Hazara University. The author has contributed to research in topics: Population & Haplogroup. The author has an hindex of 4, co-authored 9 publications receiving 223 citations. Previous affiliations of Inam Ullah include University of Copenhagen & National Defence University, Pakistan.
Topics: Population, Haplogroup, Gene pool, Steppe, Bronze Age

Papers
More filters
Journal ArticleDOI
29 Jun 2018-Science
TL;DR: Analysis of ancient whole-genome sequences from across Inner Asia and Anatolia shows that the Botai people associated with the earliest horse husbandry derived from a hunter-gatherer population deeply diverged from the Yamnaya, and suggests distinct migrations bringing West Eurasian ancestry into South Asia before and after, but not at the time of, YamNaya culture.
Abstract: The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyze 74 ancient whole-genome sequences from across Inner Asia and Anatolia and show that the Botai people associated with the earliest horse husbandry derived from a hunter-gatherer population deeply diverged from the Yamnaya. Our results also suggest distinct migrations bringing West Eurasian ancestry into South Asia before and after but not at the time of Yamnaya culture. We find no evidence of steppe ancestry in Bronze Age Anatolia from when Indo-European languages are attested there. Thus, in contrast to Europe, Early Bronze Age Yamnaya-related migrations had limited direct genetic impact in Asia.

273 citations

Journal ArticleDOI
TL;DR: The findings provide examples of both associations and dissociations between cultural and genetic legacies in these five ethnic groups, which fall mostly outside the previously characterized Y‐chromosomal gene pools of the Indo‐Pakistani subcontinent.
Abstract: The ethnic groups that inhabit the mountainous Dir and Swat districts of northern Pakistan are marked by high levels of cultural and phenotypic diversity. To obtain knowledge of the extent of genetic diversity in this region, we investigated Y-chromosomal diversity in five population samples representing the three main ethnic groups residing within these districts, including Gujars, Pashtuns and Kohistanis. A total of 27 Y-chromosomal short tandem repeats (Y-STRs) and 331 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) were investigated. In the Y-STRs, we observed very high and significant levels of genetic differentiation in nine of the 10 pairwise between-group comparisons (RST 0.179-0.746), and the differences were mirrored in the Y-SNP haplogroup frequency distribution. No genetic differences were found between the two Pashtun subethnic groups Tarklanis and Yusafzais (RST = 0.000). Utmankhels, also considered Pashtuns culturally, were not closely related to any of the other population samples (RST 0.451-0.746). Thus, our findings provide examples of both associations and dissociations between cultural and genetic legacies. When analyzed within a larger continental-scale context, these five ethnic groups fall mostly outside the previously characterized Y-chromosomal gene pools of the Indo-Pakistani subcontinent. Male founder effects, coupled with culturally and topographically based constraints upon marriage and movement, are likely responsible for the high degree of genetic structure in this region.

15 citations

Journal ArticleDOI
TL;DR: Both Rst pairwise analysis and multidimensional scaling plot showed that the genetic structure of the Yousafzais is significantly different from neighbouring populations.
Abstract: In the current study, 17 Y-Chromosomal short tandem repeats (Y-STRs) included in theAmpFlSTR Y-Filer amplification kit (Applied Biosystems, Foster City, USA) were investigated in 146 unrelated Yousafzai males residing in the Khyber Pakhtunkhwa Province of Pakistan. A total of 94 (89.52%) unique haplotypes were observed. Discrimination capacity was 71.92%. Haplotype diversity ranged from 0.354 (DYS456) to 0.663 (DYS458). Both Rst pairwise analysis and multidimensional scaling plot showed that the genetic structure of the Yousafzais is significantly different from neighbouring populations.

9 citations

Journal ArticleDOI
TL;DR: It is inferred that breeding for increased stearic acid, linolenic acid and reduced palmitic acid can be achieved through modern breeding methods and could augment the supply of edible oil as a biofuel substitute with large scale cultivation.
Abstract: Nigella sativa L. is an annual underutilized crop of enormous significance, it contains more than 100 bioactive constituents having both pharmaceutical and industrial applications. Nigella sativa L. germplasm consisting of 32 genotypes was quantified for palmitic acid, stearic acid, oleic acid, linoleic and linolenic acid and results obtained varied in percentage. Lipid extracted by chloroform methanol 2:1 (24–37 %) was higher compared to n-hexane (18–35 %) and chloroform methanol 1:3 (18–34 %). Extraction with solvent chloroform methanol 2:1 yielded a higher quantity of oil contents, hence recommended. The polyunsaturated fatty acids were higher than monounsaturated fatty acids. Stearic and palmitic acids were positively correlated as were stearic and linoleic acids. It is inferred that breeding for increased stearic acid, linolenic acid and reduced palmitic acid can be achieved through modern breeding methods. The genotypes rich in oil and oleic-linoleic acid, viz., Pk-020545, Pk-020576, Pk-020609, Pk-020620, Pk-020654, Pk-020699, Pk-020720, Pk-020780, Pk-020874 and Pk-020878, have been suggested for crop improvement programs and could augment the supply of edible oil as well as a biofuel substitute with large scale cultivation.

7 citations

Journal Article
TL;DR: The Gujar population has multiple maternal gene pool comprising of South Asian, West Eurasia, East Eurasian, Southeast Asian and fractions of Eastern Asian, Eastern Europe and Northern Asian lineages, according to mitochondrial DNA analysis.
Abstract: Background: Diversity of communities with specific cultural, ethnic, lingual and geographical backgrounds makes Pakistani society a suitable study subject to unravel the early human migrations, evolutionary history of population having about 18 ethnic groups. Gujars are mostly Indic-speaking nomadic herders with the claims of multiple origins in the sub-continent. Present study was aimed at the determination of maternal lineage of Gujars by mitochondrial DNA analysis. Methods: Total DNA from the human buccal cells was isolated using modified phenol chloroform method. Purified DNA was used for the PCR amplification of mitochondrial Hyper Variable Region 1 and 2 (HVR1 & 2). The nucleotide sequences of amplified PCR products were used to explore the maternal lineage of the Gujar population residing in Northern Pakistan. Results: Haplotypes, allele frequencies and population data of the mitochondrial control region was determined in 73 unrelated individuals belonging to Gujar ethnic group of Northwest areas of Pakistan. Total 46 diverse haplotypes were identified out of which 29 were found unique with (0.9223) genetic diversity and (0.9097) power of discrimination. Haplogroup R was the most frequent (48%) followed by haplogroup M (45%) and N (7%). Conclusion: We found that the Gujar population has multiple maternal gene pool comprising of South Asian, West Eurasian, East Eurasian, Southeast Asian and fractions of Eastern Asian, Eastern Europe and Northern Asian lineages. This study will contribute for the development of mitochondrial DNA database for Pakistani population.

5 citations


Cited by
More filters
Journal Article
Fumio Tajima1
30 Oct 1989-Genomics
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.

11,521 citations

Journal ArticleDOI
TL;DR: Submitted abstracts should clearly state the purpose, brief statement of procedure, results and conclusions, and include the name, full address and topic on all submissions.
Abstract: s should clearly state the purpose, brief statement of procedure, results and conclusions. Please include your name, full address and topic on all submissions. At least one author of each abstract should register for the conference. All accepted abstracts will be published as symposium proceedings. Additionally, commended abstracts may be published in a journal after they are expanded to a manuscript followed by extensive reviewing. The language of the conference will be English.

577 citations

Iosif Lazaridis1, Iosif Lazaridis2, Nick Patterson1, Alissa Mittnik3, Gabriel Renaud4, Swapan Mallick1, Swapan Mallick2, Karola Kirsanow5, Peter H. Sudmant6, Joshua G. Schraiber7, Joshua G. Schraiber6, Sergi Castellano4, Mark Lipson8, Bonnie Berger1, Bonnie Berger8, Christos Economou9, Ruth Bollongino5, Qiaomei Fu4, Kirsten I. Bos3, Susanne Nordenfelt1, Susanne Nordenfelt2, Heng Li2, Heng Li1, Cesare de Filippo4, Kay Prüfer4, Susanna Sawyer4, Cosimo Posth3, Wolfgang Haak10, Fredrik Hallgren11, Elin Fornander11, Nadin Rohland2, Nadin Rohland1, Dominique Delsate12, Michael Francken3, Jean-Michel Guinet12, Joachim Wahl, George Ayodo, Hamza A. Babiker13, Hamza A. Babiker14, Graciela Bailliet, Elena Balanovska, Oleg Balanovsky, Ramiro Barrantes15, Gabriel Bedoya16, Haim Ben-Ami17, Judit Bene18, Fouad Berrada19, Claudio M. Bravi, Francesca Brisighelli20, George B.J. Busby21, Francesco Calì, Mikhail Churnosov22, David E. C. Cole23, Daniel Corach24, Larissa Damba, George van Driem25, Stanislav Dryomov26, Jean-Michel Dugoujon27, Sardana A. Fedorova28, Irene Gallego Romero29, Marina Gubina, Michael F. Hammer30, Brenna M. Henn31, Tor Hervig32, Ugur Hodoglugil33, Aashish R. Jha29, Sena Karachanak-Yankova34, Rita Khusainova35, Elza Khusnutdinova35, Rick A. Kittles30, Toomas Kivisild36, William Klitz7, Vaidutis Kučinskas37, Alena Kushniarevich38, Leila Laredj39, Sergey Litvinov38, Theologos Loukidis40, Theologos Loukidis41, Robert W. Mahley42, Béla Melegh18, Ene Metspalu43, Julio Molina, Joanna L. Mountain, Klemetti Näkkäläjärvi44, Desislava Nesheva34, Thomas B. Nyambo45, Ludmila P. Osipova, Jüri Parik43, Fedor Platonov28, Olga L. Posukh, Valentino Romano46, Francisco Rothhammer47, Francisco Rothhammer48, Igor Rudan14, Ruslan Ruizbakiev49, Hovhannes Sahakyan50, Hovhannes Sahakyan38, Antti Sajantila51, Antonio Salas52, Elena B. Starikovskaya26, Ayele Tarekegn, Draga Toncheva34, Shahlo Turdikulova49, Ingrida Uktveryte37, Olga Utevska53, René Vasquez54, Mercedes Villena54, Mikhail Voevoda55, Cheryl A. Winkler56, Levon Yepiskoposyan50, Pierre Zalloua2, Pierre Zalloua57, Tatijana Zemunik58, Alan Cooper10, Cristian Capelli21, Mark G. Thomas41, Andres Ruiz-Linares41, Sarah A. Tishkoff59, Lalji Singh60, Kumarasamy Thangaraj61, Richard Villems62, Richard Villems43, Richard Villems38, David Comas63, Rem I. Sukernik26, Mait Metspalu38, Matthias Meyer4, Evan E. Eichler6, Joachim Burger5, Montgomery Slatkin7, Svante Pääbo4, Janet Kelso4, David Reich1, David Reich2, David Reich64, Johannes Krause3, Johannes Krause4 
Broad Institute1, Harvard University2, University of Tübingen3, Max Planck Society4, University of Mainz5, University of Washington6, University of California, Berkeley7, Massachusetts Institute of Technology8, Stockholm University9, University of Adelaide10, The Heritage Foundation11, National Museum of Natural History12, Sultan Qaboos University13, University of Edinburgh14, University of Costa Rica15, University of Antioquia16, Rambam Health Care Campus17, University of Pécs18, Al Akhawayn University19, Catholic University of the Sacred Heart20, University of Oxford21, Belgorod State University22, University of Toronto23, University of Buenos Aires24, University of Bern25, Russian Academy of Sciences26, Paul Sabatier University27, North-Eastern Federal University28, University of Chicago29, University of Arizona30, Stony Brook University31, University of Bergen32, Illumina33, Sofia Medical University34, Bashkir State University35, University of Cambridge36, Vilnius University37, Estonian Biocentre38, University of Strasbourg39, Amgen40, University College London41, Gladstone Institutes42, University of Tartu43, University of Oulu44, Muhimbili University of Health and Allied Sciences45, University of Palermo46, University of Tarapacá47, University of Chile48, Academy of Sciences of Uzbekistan49, Armenian National Academy of Sciences50, University of North Texas51, University of Santiago de Compostela52, University of Kharkiv53, Higher University of San Andrés54, Novosibirsk State University55, Leidos56, Lebanese American University57, University of Split58, University of Pennsylvania59, Banaras Hindu University60, Centre for Cellular and Molecular Biology61, Estonian Academy of Sciences62, Pompeu Fabra University63, Howard Hughes Medical Institute64
01 Sep 2014
TL;DR: The authors showed that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunters-gatherer related ancestry.
Abstract: We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

442 citations

Journal ArticleDOI
Vagheesh M. Narasimhan1, Nick Patterson2, Nick Patterson3, Priya Moorjani4, Nadin Rohland1, Nadin Rohland3, Rebecca Bernardos1, Swapan Mallick1, Swapan Mallick5, Swapan Mallick3, Iosif Lazaridis1, Nathan Nakatsuka1, Nathan Nakatsuka6, Iñigo Olalde1, Mark Lipson1, Alexander M. Kim1, Luca M. Olivieri, Alfredo Coppa7, Massimo Vidale8, James Mallory9, Vyacheslav Moiseyev10, Egor Kitov11, Egor Kitov10, Janet Monge12, Nicole Adamski1, Nicole Adamski5, Neel Alex4, Nasreen Broomandkhoshbacht5, Nasreen Broomandkhoshbacht1, Francesca Candilio13, Kimberly Callan1, Kimberly Callan5, Olivia Cheronet14, Olivia Cheronet13, Brendan J. Culleton15, Matthew Ferry5, Matthew Ferry1, Daniel Fernandes, Suzanne Freilich14, Beatriz Gamarra13, Daniel Gaudio13, Mateja Hajdinjak16, Eadaoin Harney1, Eadaoin Harney5, Thomas K. Harper15, Denise Keating13, Ann Marie Lawson5, Ann Marie Lawson1, Matthew Mah3, Matthew Mah1, Matthew Mah5, Kirsten Mandl14, Megan Michel1, Megan Michel5, Mario Novak13, Jonas Oppenheimer5, Jonas Oppenheimer1, Niraj Rai17, Niraj Rai18, Kendra Sirak19, Kendra Sirak1, Kendra Sirak13, Viviane Slon16, Kristin Stewardson1, Kristin Stewardson5, Fatma Zalzala5, Fatma Zalzala1, Zhao Zhang1, Gaziz Akhatov, Anatoly N. Bagashev, Alessandra Bagnera, Bauryzhan Baitanayev, Julio Bendezu-Sarmiento20, Arman A. Bissembaev, Gian Luca Bonora, T Chargynov21, T. A. Chikisheva10, Petr K. Dashkovskiy22, Anatoly P. Derevianko10, Miroslav Dobeš23, Katerina Douka16, Katerina Douka24, Nadezhda Dubova10, Meiram N. Duisengali, Dmitry Enshin, Andrey Epimakhov25, Alexey Fribus26, Dorian Q. Fuller27, Dorian Q. Fuller28, Alexander Goryachev, Andrey Gromov10, S. P. Grushin22, Bryan Hanks29, Margaret A. Judd29, Erlan Kazizov, Aleksander Khokhlov30, Aleksander P. Krygin, Elena Kupriyanova31, Pavel Kuznetsov30, Donata Luiselli32, Farhod Maksudov33, Aslan M. Mamedov, Talgat B. Mamirov, Christopher Meiklejohn34, Deborah C. Merrett35, Roberto Micheli, Oleg Mochalov30, Samariddin Mustafokulov33, Ayushi Nayak16, Davide Pettener32, Richard Potts36, Dmitry Razhev, Marina Petrovna Rykun37, Stefania Sarno32, Tatyana M. Savenkova, Kulyan Sikhymbaeva, Sergey Mikhailovich Slepchenko, Oroz A. Soltobaev21, Nadezhda Stepanova10, Svetlana V. Svyatko10, Svetlana V. Svyatko9, Kubatbek Tabaldiev, Maria Teschler-Nicola14, Maria Teschler-Nicola38, Alexey A. Tishkin22, Vitaly V. Tkachev, Sergey Vasilyev10, Petr Velemínský39, Dmitriy Voyakin, Antonina Yermolayeva, Muhammad Zahir40, Muhammad Zahir16, Valery S. Zubkov, A. V. Zubova10, Vasant Shinde41, Carles Lalueza-Fox42, Matthias Meyer16, David W. Anthony43, Nicole Boivin16, Kumarasamy Thangaraj17, Douglas J. Kennett15, Douglas J. Kennett44, Michael D. Frachetti45, Ron Pinhasi13, Ron Pinhasi14, David Reich 
06 Sep 2019-Science
TL;DR: It is shown that Steppe ancestry then integrated further south in the first half of the second millennium BCE, contributing up to 30% of the ancestry of modern groups in South Asia, supporting the idea that the archaeologically documented dispersal of domesticates was accompanied by the spread of people from multiple centers of domestication.
Abstract: By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.

354 citations