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Inderchand Manjubala

Bio: Inderchand Manjubala is an academic researcher from VIT University. The author has contributed to research in topics: Carboxymethyl cellulose & Bone regeneration. The author has an hindex of 30, co-authored 50 publications receiving 2383 citations. Previous affiliations of Inderchand Manjubala include Central Leather Research Institute & University of Jena.


Papers
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01 Apr 2020-Heliyon
TL;DR: This paper focuses on the commercially available hydrogels used for biomedical applications like wound dressings, contact lenses, cosmetic applications, tissue engineering, and drug delivery.

223 citations

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TL;DR: The in-vitro cytocompatibility tests with osteoblast-like cells (Saos-2) demonstrated that the biomineralised scaffold is a suitable substrate for cell attachment and migration in bone tissue engineering.

177 citations

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TL;DR: A simple self-assembly route leading to a CaCO3 microlens array, somewhat reminiscent of the brittlestars' microlenses, is described, by using a minimum number of components and equipment at ambient conditions, showing that advanced optical materials can be generated by a simple mineral precipitation.
Abstract: Biological materials efficiently exploit self-assembly of simple constituents to produce complex functional structures such as optical devices. By controlling organic molecules, Lee et al. show fast two-step self-assembly of CaCO3 microlens arrays, reminiscent of their biological counterparts.

154 citations

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TL;DR: Nf1 has an important role in the development of joints, as shown by fusion of the hip joints and other joint abnormalities, which are not observed in neurofibromatosis type I, and has multiple essential roles in skeletal development and growth.
Abstract: Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the formation of neurofibromas, cafe´-au-lait spots and freckling. Skeletal abnormalities such as short stature or bowing/pseudarthrosis of the tibia are relatively common. To investigate the role of the neurofibromin in skeletal development, we crossed Nf1flox mice with Prx1Cre mice to inactivate Nf1 in undifferentiated mesenchymal cells of the developing limbs. Similar to NF1 affected individuals, Nf1 Prx1 mice show bowing of the tibia and diminished growth. Tibial bowing is caused by decreased stability of the cortical bone due to a high degree of porosity, decreased stiffness and reduction in the mineral content as well as hyperosteoidosis. Accordingly, osteoblasts show an increase in proliferation and a decreased ability to differentiate and mineralize in vitro. The reduction in growth is due to lower proliferation rates and a differentiation defect of chondrocytes. Abnormal vascularization of skeletal tissues is likely to contribute to this pathology as it exerts a negative effect on cortical bone stability. Furthermore, Nf1 has an important role in the development of joints, as shown by fusion of the hip joints and other joint abnormalities, which are not observed in neurofibromatosis type I. Thus, neurofibromin has multiple essential roles in skeletal development and growth.

122 citations

Journal ArticleDOI
01 Dec 2011-Bone
TL;DR: The data of the present study indicate that β-APN treatment changed whole vertebra properties compared to non-treated rats, including collagen cross-links pattern, trabecular bone volume to tissue ratio and trABecular thickness, which were all decreased.

121 citations


Cited by
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01 Jan 2007
TL;DR: The Third edition of the Kirk-Othmer encyclopedia of chemical technology as mentioned in this paper was published in 1989, with the title "Kirk's Encyclopedia of Chemical Technology: Chemical Technology".
Abstract: 介绍了Kirk—Othmer Encyclopedia of Chemical Technology(化工技术百科全书)(第五版)电子图书网络版数据库,并对该数据库使用方法和检索途径作出了说明,且结合实例简单地介绍了该数据库的检索方法。

2,666 citations

Journal ArticleDOI
TL;DR: This review summarizes the most recent advances in the field over the past 4 years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.
Abstract: Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant advantage of being able to be broken down and removed after they have served their function. Applications are wide ranging with degradable polymers being used clinically as surgical sutures and implants. In order to fit functional demand, materials with desired physical, chemical, biological, biomechanical and degradation properties must be selected. Fortunately, a wide range of natural and synthetic degradable polymers has been investigated for biomedical applications with novel materials constantly being developed to meet new challenges. This review summarizes the most recent advances in the field over the past 4 years, specifically highlighting new and interesting discoveries in tissue engineering and drug delivery applications.

1,712 citations

Journal ArticleDOI
TL;DR: This article is focused on nanosized HAp, although recent articles on microsized particles, especially those assembled from nanoparticles and/or nanocrystals, have been reviewed for comparison.

1,036 citations

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TL;DR: Current biomedical applications of calcium orthophosphate bioceramics include replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmentation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery.

1,019 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the role played by biological calcium phosphates in bone regeneration is presented, where the synthesis procedures to obtain in the laboratory calcium deficient carbonate nanoapatite both in bulk and thin film forms, as well as the characterization methods applied to these materials are described.

1,014 citations