Showing papers by "Indrapal Singh Aidhen published in 2001"
TL;DR: In this article, a three carbon homologation of α-aminonitrile was developed for the synthesis of unsymmetrical 1,4-diketones.
15 citations
10 citations
TL;DR: In this paper, a three carbon homologation of α-aminonitrile was developed for the synthesis of unsymmetrical 1,4-diketones.
Abstract: A synthetic route based on a three carbon homologation of an α-aminonitrile was developed for the synthesis of unsymmetrical 1,4-diketones. The key steps were the alkylation of various aryl and heteroaryl α-aminonitriles with N-methoxy-N-methyl-3-bromopropionamide followed by the addition of a Grignard reagent to the alkylated product and then subsequent hydrolysis.
2 citations
TL;DR: Aryl and hetero-terahydrofuranols (2a-h) have been conveniently prepared in good yields by reaction of synthetic equivalents of an acyl anion and a β-electrophilic propionaldehyde as mentioned in this paper.
Abstract: Various aryl and heteroarylterahydrofuranols (2a–h) have been conveniently prepared in good yields by reaction of synthetic equivalents of an acyl anion and a β-electrophilic propionaldehyde.