scispace - formally typeset
Search or ask a question

Showing papers by "Indrapal Singh Aidhen published in 2014"


Journal ArticleDOI
TL;DR: In this paper, the metal-free oxidation of o-vinyl diaryl ketones in the presence of molecular iodine or N-iodosuccinimide was described.

14 citations


Journal ArticleDOI
TL;DR: In this article, the molecular level understanding of interaction between Fingolimod hydrochloride and dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLVs) as a drug molecule carrier was investigated by investigating the structural changes, solubilisation effect and thermotropic phase behaviour.
Abstract: This work focuses on the molecular level understanding of interaction between FTY720 (Fingolimod hydrochloride) and dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLVs) as a drug molecule carrier by investigating the structural changes, solubilisation effect and thermotropic phase behaviour. Three different techniques like dynamic light scattering (DLS), differential scanning calorimetry (DSC) and fluorescent molecular probe based techniques were used to study the effect of FTY720 on DMPC MLVs. DLS studies showed that FTY720 induces a marked change in the DMPC MLVs' structure and solubilises the lipid membrane with the increase in concentration of FTY720. DSC and temperature dependent fluorescence intensity studies of 1-naphthol showed that FTY720 broadens and shifts the phase transition temperature of the DMPC MLVs to a lower temperature. This is in contrast to the effect of the sphingosine which is a structural analogous to FTY720. Fluorescence anisotropy study of 1,6-diphenyl-1,3,5-hexatriene (DPH) also revealed the above phenomena. Fluorescence lifetime decay analysis of 1-naphthol suggested that incorporation of FTY720 causes a redistribution of 1-naphthol molecules between the core and interfacial regions of the membrane.

4 citations


Journal ArticleDOI
TL;DR: In this article, a metal-free oxidation of o-vinyl diaryl ketones to diacylbenzene derivatives is described, and a new metal free method is proposed.
Abstract: A new metal-free oxidation of o-vinyl diaryl ketones to diacylbenzene derivatives is described.

2 citations


Journal ArticleDOI
TL;DR: In this article, a suitable building block for the synthesis of vinyl ketones on a multigram scale via addition of Grignard reagents and subsequent oxidation was proposed. But the synthesis was not carried out in a multi-stage manner.
Abstract: Hitherto unknown amide (III) is a suitable building block for the synthesis of vinyl ketones on a multigram scale via addition of Grignard reagents and subsequent oxidation.

Journal ArticleDOI
TL;DR: An interesting formation of bis(5-arylfuran-2-yl)methanes involving TFA-mediated dimerization of enantiopure tartaric acid derived ketones (III and V) was described in this article.
Abstract: An interesting formation of bis(5-arylfuran-2-yl)methanes is described involving TFA-mediated dimerization of enantiopure tartaric acid derived ketones (III) and (V).