Showing papers by "Indrapal Singh Aidhen published in 2017"
TL;DR: In this paper, a new route for the synthesis of 3-substituted and 8-hydroxy-3-substantituted isocoumarins has been developed by using modified Julia olefination for initial C-C bond formation between aldehydes and benzylic-sulfones.
11 citations
TL;DR: In this paper, Weinreb amide (WA) based building block derived from glycolic acid has been developed for assembling diarylmethine unit present in biologically important molecules.
5 citations
4 citations
TL;DR: Total synthesis of naturally occurring Oxylipin has been achieved from open chain gluco-configured building block which is readily assembled from inexpensive and commercially available D-(+)-gluconolactone.
3 citations
TL;DR: In this article, a series of threo - and erythro -configured open-chain trihydroxy ketones was synthesized starting from l - and d -ascorbic acid respectively as the starting material, through the use of Grignard reactions for the requisite C C bond formations.
Abstract: A series of threo - and erythro -configured open-chain trihydroxy ketones was synthesized starting from l - and d -ascorbic acid respectively as the starting material, through the use of Grignard reactions for the requisite C C bond formations. The lipophilic ketones were screened against Mycobacteriumtuberculosis for anti-proliferative activity. The lipophilic ketones with tetradecyl alkyl side chains were found to be moderately active against cell proliferation.
3 citations
TL;DR: A new functionalised sulphone-based building block has been synthesised that enabled C-C bond formation through Julia olefination and the utility of developed building block was demonstrated by successful synthesis of two natural products lunularic acid, hydrangeic acid and initial libraries of their analogues.
3 citations