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Inge K. Herrmann

Other affiliations: Imperial College London, University of St. Gallen, ETH Zurich  ...read more
Bio: Inge K. Herrmann is an academic researcher from Swiss Federal Laboratories for Materials Science and Technology. The author has contributed to research in topics: Medicine & Nanoparticle. The author has an hindex of 22, co-authored 76 publications receiving 1374 citations. Previous affiliations of Inge K. Herrmann include Imperial College London & University of St. Gallen.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors discuss the biological role of extracellular vesicles and how they can be applied as drug carriers, focusing on the current state of their manufacturing and existing challenges.
Abstract: Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of life. There is compelling evidence that extracellular vesicles are involved in major (patho)physiological processes, including cellular homoeostasis, infection propagation, cancer development and cardiovascular diseases. Various studies suggest that extracellular vesicles have several advantages over conventional synthetic carriers, opening new frontiers for modern drug delivery. Despite extensive research, clinical translation of extracellular-vesicle-based therapies remains challenging. Here, we discuss the uniqueness of extracellular vesicles along with critical design and development steps required to utilize their full potential as drug carriers, including loading methods, in-depth characterization and large-scale manufacturing. We compare the prospects of extracellular vesicles with those of the well established liposomes and provide guidelines to direct the process of developing vesicle-based drug delivery systems. In this Review the authors discuss the biological role of extracellular vesicles and how they can be applied as drug carriers, focusing on the current state of their manufacturing and existing challenges.

481 citations

Journal ArticleDOI
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to natural disasters.
Abstract: [This corrects the article DOI: 10.1186/s13054-016-1208-6.].

180 citations

Journal ArticleDOI
TL;DR: In this article, the authors demonstrate the production of iron-based nanoparticles, ranging from iron oxide to iron and iron carbide, by systematically modifying the degree of reduction during flame spray synthesis under a controlled atmosphere.
Abstract: The rapidly growing applications of nanomagnets require acid/base stable, oxidation-resistant shells with chemically controlled surface structure. An ideal core should be metallic and highly magnetic. We demonstrate the production of iron-based nanoparticles, ranging from iron oxide to iron and iron carbide, by systematically modifying the degree of reduction during flame spray synthesis under a controlled atmosphere. At a laboratory scale, continuous production yields iron-based particles of 20−50 nm at a production rate of >10 g h−1. Carbon-encapsulated iron carbide (C/Fe3C) combines exceptionally high saturation magnetization (140 emu g−1), air stability (up to 200 °C), and resistance against acidic dissolution (1 week in 24% HCl). The top graphene-like carbon layer could be covalently functionalized with various linkers, thus allowing us to chemically design the particle surface. Activity was demonstrated by reacting 2-phenyl ethyl amine functionalized nanomagnets with carboxylic acid chlorides as a m...

136 citations

Journal ArticleDOI
TL;DR: It is shown how cell-derived vesicles can be harvested and engineered to meet application-specific design requirements and potential risks encountered when translating extracellular vesicle based approaches into (pre)clinical applications are discussed.

112 citations


Cited by
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Journal ArticleDOI

[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 Jan 2016
TL;DR: The the essential physics of medical imaging is universally compatible with any devices to read, and is available in the digital library an online access to it is set as public so you can get it instantly.
Abstract: Thank you very much for reading the essential physics of medical imaging. As you may know, people have search hundreds times for their chosen novels like this the essential physics of medical imaging, but end up in harmful downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they juggled with some infectious virus inside their laptop. the essential physics of medical imaging is available in our digital library an online access to it is set as public so you can get it instantly. Our digital library saves in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Merely said, the the essential physics of medical imaging is universally compatible with any devices to read.

632 citations

Journal ArticleDOI
TL;DR: In this article, the authors summarize the representative methods for the synthesis of well-defined uncoated and coated magnetic nanomaterials and the most common synthetic approaches to attach or immobilize non-magnetic catalytic active phases onto magnetic nano-materials.

484 citations

Journal ArticleDOI
TL;DR: In this paper, the authors discuss the biological role of extracellular vesicles and how they can be applied as drug carriers, focusing on the current state of their manufacturing and existing challenges.
Abstract: Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of life. There is compelling evidence that extracellular vesicles are involved in major (patho)physiological processes, including cellular homoeostasis, infection propagation, cancer development and cardiovascular diseases. Various studies suggest that extracellular vesicles have several advantages over conventional synthetic carriers, opening new frontiers for modern drug delivery. Despite extensive research, clinical translation of extracellular-vesicle-based therapies remains challenging. Here, we discuss the uniqueness of extracellular vesicles along with critical design and development steps required to utilize their full potential as drug carriers, including loading methods, in-depth characterization and large-scale manufacturing. We compare the prospects of extracellular vesicles with those of the well established liposomes and provide guidelines to direct the process of developing vesicle-based drug delivery systems. In this Review the authors discuss the biological role of extracellular vesicles and how they can be applied as drug carriers, focusing on the current state of their manufacturing and existing challenges.

481 citations

Journal ArticleDOI
Wendelin J. Stark1
TL;DR: The interaction of particles with biology unravels a series of new mechanisms not found for molecules: altered biodistribution, chemically reactive interfaces, and the combination of solid-state properties and mobility.
Abstract: Understanding the behavior of nanoparticles in biological systems opens up new directions for medical treatments and is essential for the development of safe nanotechnology. This Review discusses molecules and nanoparticles when in contact with cells or whole organisms, with a focus on inorganic materials. The interaction of particles with biology unravels a series of new mechanisms not found for molecules: altered biodistribution, chemically reactive interfaces, and the combination of solid-state properties and mobility. Externally guided movement of medicaments by using functional nanomagnets brings mechanics into drug design. In subsequent sections, the role of inertness and bioaccumulation is discussed in regard to the long-term safety of nanoparticles.

477 citations