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Ioannis Grammatikakis
Researcher at National Institutes of Health
Publications - 41
Citations - 4094
Ioannis Grammatikakis is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 22, co-authored 34 publications receiving 2949 citations. Previous affiliations of Ioannis Grammatikakis include Baylor College of Medicine & Cross Cancer Institute.
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Journal ArticleDOI
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs
Dawood B. Dudekula,Amaresh C. Panda,Ioannis Grammatikakis,Supriyo De,Kotb Abdelmohsen,Myriam Gorospe +5 more
TL;DR: A new web tool, CircInteractome (circRNA interactome), is presented, freely accessible at http://circinteractome.nia.nih.gov, for mapping RBP- and miRNA-binding sites on human circRNAs.
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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.
Kotb Abdelmohsen,Amaresh C. Panda,Rachel Munk,Ioannis Grammatikakis,Dawood B. Dudekula,Supriyo De,Jiyoung Kim,Ji Heon Noh,Kyoung Mi Kim,Jennifer L. Martindale,Myriam Gorospe +10 more
TL;DR: It is proposed that the extensive binding of CircPABPN1 to HuR prevents HuR binding to P ABPN1 mRNA and lowers PABPN1 translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP that affects translation.
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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model.
Peisu Zhang,Yuki Kishimoto,Ioannis Grammatikakis,Kamalvishnu P. Gottimukkala,Roy G. Cutler,Shiliang Zhang,Kotb Abdelmohsen,Vilhelm A. Bohr,Jyoti Misra Sen,Jyoti Misra Sen,Myriam Gorospe,Mark P. Mattson,Mark P. Mattson +12 more
TL;DR: A role for Aβ-induced OPC cell senescence in neuroinflammation and cognitive deficits in AD is suggested, and a potential therapeutic benefit of senolytic treatments is suggested.
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Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines: Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells
Quan Lin,Raymond Lai,Lucian R. Chirieac,Changping Li,Vilmos A. Thomazy,Ioannis Grammatikakis,George Z. Rassidakis,Wei Zhang,Yasushi Fujio,Keita Kunisada,Stanley R. Hamilton,Hesham M. Amin +11 more
TL;DR: In this paper, the authors demonstrate that activated STAT3 and activated JAK3 (pSTAT3) are expressed constitutively in two colon cancer cell lines, SW480 and HT29.
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Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.
Amaresh C. Panda,Ioannis Grammatikakis,Kyoung Mi Kim,Supriyo De,Jennifer L. Martindale,Rachel Munk,Xiaoling Yang,Kotb Abdelmohsen,Myriam Gorospe +8 more
TL;DR: Findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype.