Irena Loryan

TL;DR: There was a pronounced effect of sex, a finding that indicates an important factor for the previously described sex difference in systemic clearance of propofol seen, and was supported by in vitro data showing similar variability of prop ofol 4-hydroxylation in liver microsomes.

TL;DR: A detailed protocol for the rat and mouse brain slice methods is provided, with the aim of enabling simple, cost-effective profiling of compounds with diverse physicochemical properties, for estimation of target-site pharmacokinetics in the early drug discovery process and fundamental pharmacological studies.

TL;DR: Integration of the neuroPK parameters with pharmacodynamic readouts demonstrated the value of the proposed approach in the evaluation of target engagement and NCE selection, thereby optimizing the routine of evaluation and selection of novel neurotherapeutics.

TL;DR: Interpretable molecular descriptors that significantly contribute to the three key neuropharmacokinetic properties related to BBB drug transport, intracellular accumulation, and binding and distribution in the brain for a set of 40 compounds were identified using partial least-squares analysis.

TL;DR: The observed regional differences in BBB penetration may potentially be important factors contributing to variations in therapeutic effect and side effect profiles among antipsychotic drugs.