Irene Hollfinger

TL;DR: A circRNA expression resource of 20 human tissues highly relevant to disease-related research is presented and evidence for differential circRNAs expression of genes that are involved in the molecular pathogenesis of both phenotypes is found.

TL;DR: A new model is proposed in which YAP/TAZ integrate mechanical signals with BMP signaling to maintain junctional compliance and integrity whilst balancing endothelial cell rearrangements in angiogenic vessels.

TL;DR: It is suggested that the identified PDE3A mutations cause mendelian hypertension, a syndrome that features brachydactyly type E, severe salt-independent but age-dependent hypertension, an increased fibroblast growth rate, neurovascular contact at the rostral-ventrolateral medulla, altered baroreflex blood pressure regulation and death from stroke before age 50 years when untreated.

TL;DR: In this article, the authors show that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress.

TL;DR: In this article, the authors used flow-induced shear stress and VEGF-A treatment on endothelial cells in vitro, showing that the response to the magnitude of a mechanical stimulus is influenced by the concentration of a chemical stimulus, and vice versa.