I
Irene Keller
Researcher at Swiss Institute of Bioinformatics
Publications - 74
Citations - 6002
Irene Keller is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Population & Genetic structure. The author has an hindex of 27, co-authored 69 publications receiving 5123 citations. Previous affiliations of Irene Keller include ETH Zurich & Swiss Ornithological Institute.
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Journal ArticleDOI
Genomics and the origin of species
Ole Seehausen,Roger K. Butlin,Irene Keller,Catherine E. Wagner,Janette W. Boughman,Paul A. Hohenlohe,Catherine L. Peichel,Glenn-Peter Sætre,Claudia Bank,Åke Brännström,Alan Brelsford,Chris S Clarkson,Fabrice Eroukhmanoff,Jeffrey L. Feder,Martin C. Fischer,Andrew D. Foote,Paolo Franchini,Chris D. Jiggins,Felicity C. Jones,Anna K. Lindholm,Kay Lucek,Martine E. Maan,David Alexander Marques,Simon H. Martin,Blake Matthews,Joana I. Meier,Markus Möst,Michael W. Nachman,Etsuko Nonaka,Diana J. Rennison,Julia Schwarzer,E. Watson,Anja M. Westram,Alex Widmer +33 more
TL;DR: Emergent trends and gaps in understanding are identified, new approaches to more fully integrate genomics into speciation research are proposed, and an integrative definition of the field of speciation genomics is provided.
Journal ArticleDOI
The genomic substrate for adaptive radiation in African cichlid fish
David Brawand,David Brawand,Catherine E. Wagner,Catherine E. Wagner,Yang I. Li,Milan Malinsky,Milan Malinsky,Irene Keller,Shaohua Fan,Oleg Simakov,Alvin Yu Jin Ng,Zhi Wei Lim,Etienne Bezault,Jason Turner-Maier,Jeremy A. Johnson,Rosa Alcazar,Hyun Ji Noh,Pamela Russell,Bronwen Aken,Jessica Alföldi,Chris T. Amemiya,Naoual Azzouzi,Jean-François Baroiller,Frédérique Barloy-Hubler,Aaron M. Berlin,Ryan F. Bloomquist,Karen L. Carleton,Matthew A. Conte,Helena D'Cotta,Orly Eshel,Leslie Gaffney,Francis Galibert,Hugo F. Gante,Sante Gnerre,Lucie Greuter,Lucie Greuter,Richard Guyon,Natalie S. Haddad,Wilfried Haerty,Robert M Harris,Hans A. Hofmann,Thibaut Hourlier,Gideon Hulata,David B. Jaffe,Marcia Lara,Alison P. Lee,Iain MacCallum,Salome Mwaiko,Masato Nikaido,Hidenori Nishihara,Catherine Ozouf-Costaz,David J. Penman,Dariusz Przybylski,Michaelle Rakotomanga,Suzy C. P. Renn,Filipe J. Ribeiro,Micha Ron,Walter Salzburger,Luis Sanchez-Pulido,M. Emília Santos,Steve Searle,Ted Sharpe,Ross Swofford,Frederick J. Tan,Louise Williams,Sarah Young,Shuangye Yin,Norihiro Okada,Norihiro Okada,Thomas D. Kocher,Eric A. Miska,Eric S. Lander,Byrappa Venkatesh,Russell D. Fernald,Axel Meyer,Chris P. Ponting,J. Todd Streelman,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Ole Seehausen,Ole Seehausen,Federica Di Palma,Federica Di Palma +82 more
TL;DR: This article found an excess of gene duplications in the East African lineage compared to Nile tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.
The genomic substrate for adaptive radiation in African cichlid fish
David Brawand,David Brawand,Catherine E. Wagner,Catherine E. Wagner,Yang I. Li,Milan Malinsky,Milan Malinsky,Irene Keller,Shaohua Fan,Oleg Simakov,Alvin Yu Jin Ng,Zhi Wei Lim,Etienne Bezault,Jason Turner-Maier,Jeremy A. Johnson,Rosa Alcazar,Hyun Ji Noh,Pamela Russell,Bronwen Aken,Jessica Alföldi,Chris T. Amemiya,Naoual Azzouzi,Jean-François Baroiller,Frédérique Barloy-Hubler,Aaron M. Berlin,Ryan F. Bloomquist,Karen L. Carleton,Matthew A. Conte,Helena D'Cotta,Orly Eshel,Leslie Gaffney,Francis Galibert,Hugo F. Gante,Sante Gnerre,Lucie Greuter,Lucie Greuter,Richard Guyon,Natalie S. Haddad,Wilfried Haerty,Robert M Harris,Hans A. Hofmann,Thibaut Hourlier,Gideon Hulata,David B. Jaffe,Marcia Lara,Alison P. Lee,Iain MacCallum,Salome Mwaiko,Masato Nikaido,Hidenori Nishihara,Catherine Ozouf-Costaz,David J. Penman,Dariusz Przybylski,Michaelle Rakotomanga,Suzy C. P. Renn,Filipe J. Ribeiro,Micha Ron,Walter Salzburger,Luis Sanchez-Pulido,M. Emília Santos,Steve Searle,Ted Sharpe,Ross Swofford,Frederick J. Tan,Louise Williams,Sarah Young,Shuangye Yin,Norihiro Okada,Norihiro Okada,Thomas D. Kocher,Eric A. Miska,Eric S. Lander,Byrappa Venkatesh,Russell D. Fernald,Axel Meyer,Chris P. Ponting,J. Todd Streelman,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Ole Seehausen,Ole Seehausen,Federica Di Palma,Federica Di Palma +82 more
TL;DR: It is concluded that a number of molecular mechanisms shaped East African cichlid genomes, and that amassing of standing variation during periods of relaxed purifying selection may have been important in facilitating subsequent evolutionary diversification.
Journal ArticleDOI
Genome-wide RAD sequence data provide unprecedented resolution of species boundaries and relationships in the Lake Victoria cichlid adaptive radiation
Catherine E. Wagner,Irene Keller,Irene Keller,Samuel Wittwer,Samuel Wittwer,Oliver M. Selz,Oliver M. Selz,Salome Mwaiko,Salome Mwaiko,Lucie Greuter,Lucie Greuter,Arjun Sivasundar,Arjun Sivasundar,Ole Seehausen,Ole Seehausen +14 more
TL;DR: This work uses NGS data generated from reduced representation genomic libraries of restriction‐site‐associated DNA (RAD) markers to infer phylogenetic relationships among 16 species of cichlid fishes from a single rocky island community within Lake Victoria's cICHlid adaptive radiation, and produces phylogenetic trees with unprecedented resolution for this group.
Journal ArticleDOI
The outer mucus layer hosts a distinct intestinal microbial niche
Hai Li,Julien P. Limenitakis,Tobias Fuhrer,Markus B. Geuking,Melissa A. E. Lawson,Madeleine Wyss,Sandrine Brugiroux,Irene Keller,Jamie A. Macpherson,Sandra Rupp,Bettina Stolp,Jens V. Stein,Bärbel Stecher,Uwe Sauer,Kathleen McCoy,Andrew J. Macpherson +15 more
TL;DR: It is shown that the outer mucus of the large intestine forms a unique microbial niche with distinct communities, including bacteria without specialized mucolytic capability, and bacterial species present in the mucus show differential proliferation and resource utilization compared with the same species in the intestinal lumen.