Irina A. Sevostyanova

TL;DR: This review summarizes the results of studies on the kinetics of the interaction of ThDP with TK from Saccharomyces cerevisae as well as the generation of the catalytically active form of the coenzyme within the holoenzyme and formation of the enzyme's active center.

TL;DR: Yeast transketolase, in addition to catalyzing the transferase reaction through utilization of two substrates--the donor substrate (ketose) and the acceptor substrate (aldose)--is also able to catalyze a one-substrate reaction with only aldose (glycolaldehyde) as substrate.

TL;DR: The ability of HCA derivatives to preventAmyloid transformation of some amyloidogenic proteins, and their presence not only in food products but also as natural metabolites in human blood and tissues, makes them promising for the prevention and treatment of neurodegenerative diseases of amyloids nature.

TL;DR: The results suggest that GAPDS is expressed in melanoma cells without N-terminal domain, and indicates that melanoma Cells express both isoenzymes, which results in the formation of heterotetrameric complexes.

TL;DR: In the presence of magnesium, the active centers of the enzyme were functionally equivalent with respect to xylulose 5‐phosphate binding and exhibited identical affinities for the donor substrate, but substitution of Ca2+ for Mg2+ results in the loss of the equivalence.