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Irina Alafuzoff
Researcher at Uppsala University
Publications - 247
Citations - 22786
Irina Alafuzoff is an academic researcher from Uppsala University. The author has contributed to research in topics: Alzheimer's disease & Dementia. The author has an hindex of 71, co-authored 242 publications receiving 19635 citations. Previous affiliations of Irina Alafuzoff include University of Eastern Finland & Oulu University Hospital.
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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry.
TL;DR: To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis.
Journal ArticleDOI
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Peter T. Nelson,Irina Alafuzoff,Eileen H. Bigio,Constantin Bouras,Heiko Braak,Nigel J. Cairns,Rudolph J. Castellani,Barbara J. Crain,Peter Davies,Kelly Del Tredici,Charles Duyckaerts,Matthew P. Frosch,Vahram Haroutunian,Patrick R. Hof,Christine M. Hulette,Bradley T. Hyman,Takeshi Iwatsubo,Kurt A. Jellinger,Gregory A. Jicha,Eniko Veronika Kovari,Walter A. Kukull,James B. Leverenz,Seth Love,Seth Love,Ian R. A. Mackenzie,David M. A. Mann,Eliezer Masliah,Ann C. McKee,Thomas J. Montine,John C. Morris,Julie A. Schneider,Joshua A. Sonnen,Dietmar Rudolf Thal,John Q. Trojanowski,Juan C. Troncoso,Thomas Wisniewski,Randall L. Woltjer,Thomas G. Beach +37 more
TL;DR: Evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of A&bgr; plaques and neurofibrillary tangles.
Journal ArticleDOI
Primary age-related tauopathy (PART): a common pathology associated with human aging
John F. Crary,John Q. Trojanowski,Julie A. Schneider,Jose F. Abisambra,Erin L. Abner,Irina Alafuzoff,Steven E. Arnold,Johannes Attems,Thomas G. Beach,Eileen H. Bigio,Nigel J. Cairns,Dennis W. Dickson,Marla Gearing,Lea T. Grinberg,Lea T. Grinberg,Patrick R. Hof,Bradley T. Hyman,Kurt A. Jellinger,Gregory A. Jicha,Gabor G. Kovacs,David S. Knopman,Julia Kofler,Walter A. Kukull,Ian R. A. Mackenzie,Eliezer Masliah,Ann C. McKee,Thomas J. Montine,Melissa E. Murray,Janna H. Neltner,Ismael Santa-Maria,William W. Seeley,Alberto Serrano-Pozo,Michael L. Shelanski,Thor D. Stein,Masaki Takao,Dietmar Rudolf Thal,Jonathan B. Toledo,Juan C. Troncoso,Jean Paul G. Vonsattel,Charles L. White,Thomas Wisniewski,Randall L. Woltjer,Masahito Yamada,Peter T. Nelson +43 more
TL;DR: A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time.
Journal ArticleDOI
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
Ian R. A. Mackenzie,Manuela Neumann,Eileen H. Bigio,Nigel J. Cairns,Irina Alafuzoff,Jillian J. Kril,Gabor G. Kovacs,Bernardino Ghetti,Glenda M. Halliday,Ida E. Holm,Paul G. Ince,Wouter Kamphorst,Tamas Revesz,Annemieke J.M. Rozemuller,Samir Kumar-Singh,Haruhiko Akiyama,Atik Baborie,Salvatore Spina,Dennis W. Dickson,John Q. Trojanowski,David M. A. Mann +20 more
TL;DR: A system of nosology was introduced that grouped the FTLD subtypes into broad categories, based on the molecular defect that is most characteristic, according to current evidence, and provided a concise and consistent terminology that has now been widely adopted in the literature.
Journal ArticleDOI
Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain
Tero Tapiola,Irina Alafuzoff,Sanna-Kaisa Herukka,Laura Parkkinen,Päivi Hartikainen,Hilkka Soininen,Tuula Pirttilä +6 more
TL;DR: Cerebrospinal fluid Abeta42 and tau proteins are biomarkers of AD-associated pathologic changes in the brain and the combination of abnormally low CSF Abeta 42 level and abnormally high CSF tau level predicted the presence of AD pathologic features with high accuracy.