I
Irsan E. Kooi
Researcher at VU University Medical Center
Publications - 17
Citations - 1346
Irsan E. Kooi is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Retinoblastoma & Chromosome instability. The author has an hindex of 12, co-authored 16 publications receiving 950 citations. Previous affiliations of Irsan E. Kooi include VU University Amsterdam.
Papers
More filters
Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes
Irsan E. Kooi,Berber M. Mol,Maarten P.G. Massink,Najim Ameziane,Hanne Meijers-Heijboer,Charlotte J. Dommering,Saskia E. van Mil,Yne de Vries,Annemarie H. van der Hout,Gertjan J.L. Kaspers,Annette C. Moll,Hein te Riele,Jacqueline Cloos,Josephine C. Dorsman +13 more
TL;DR: It is hypothesized that retinoblastomas arising later in retinal development benefit more from subclonal secondary alterations and therefore, these alterations are more selected for in these tumors, suggesting within-tumor heterogeneity.
Journal ArticleDOI
Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma.
Jesse L. Berry,Liya Xu,Irsan E. Kooi,A. Linn Murphree,A. Linn Murphree,Rishvanth K. Prabakar,Mark W. Reid,Kevin Stachelek,Bao Han A. Le,Bao Han A. Le,Lisa Welter,Bibiana J. Reiser,Bibiana J. Reiser,Patricia Chévez-Barrios,Rima Jubran,Thomas C. Lee,Thomas C. Lee,Jonathan W. Kim,Jonathan W. Kim,Peter Kuhn,David Cobrinik,James W. Hicks +21 more
TL;DR: This is the first study to correlate clinical outcomes with SCNAs in the AH from retinoblastoma eyes, as such these findings indicate that 6p gain in the aqueous humor is a potential prognostic biomarker for poor clinical response to therapy.
Journal ArticleDOI
A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression.
Irsan E. Kooi,Berber M. Mol,Maarten P.G. Massink,Marcus C. de Jong,Pim de Graaf,Paul van der Valk,Hanne Meijers-Heijboer,Gertjan J.L. Kaspers,Annette C. Moll,Hein te Riele,Jacqueline Cloos,Josephine C. Dorsman +11 more
TL;DR: A comprehensive meta-analysis of genome-wide SCNAs integrated with gene expression profiling data, narrowing down the list of plausible retinoblastoma driver genes and shows that copy number gains rarely exceeded change of one copy, even in pure tumor samples with 100% homozygosity at the RB1 locus, indicative for intra-tumor heterogeneity.