Iryna Posokhova

Bio: Iryna Posokhova is an academic researcher from Kharkiv National Medical University. The author has contributed to research in topics: Machine learning & Artificial intelligence. The author has an hindex of 3, co-authored 4 publications receiving 314 citations.

AI4COVID-19: AI Enabled Preliminary Diagnosis for COVID-19 from Cough Samples via an App

Abstract: Background: The inability to test at scale has become humanity's Achille's heel in the ongoing war against the COVID-19 pandemic. A scalable screening tool would be a game changer. Building on the prior work on cough-based diagnosis of respiratory diseases, we propose, develop and test an Artificial Intelligence (AI)-powered screening solution for COVID-19 infection that is deployable via a smartphone app. The app, named AI4COVID-19 records and sends three 3-second cough sounds to an AI engine running in the cloud, and returns a result within two minutes. Methods: Cough is a symptom of over thirty non-COVID-19 related medical conditions. This makes the diagnosis of a COVID-19 infection by cough alone an extremely challenging multidisciplinary problem. We address this problem by investigating the distinctness of pathomorphological alterations in the respiratory system induced by COVID-19 infection when compared to other respiratory infections. To overcome the COVID-19 cough training data shortage we exploit transfer learning. To reduce the misdiagnosis risk stemming from the complex dimensionality of the problem, we leverage a multi-pronged mediator centered risk-averse AI architecture. Results: Results show AI4COVID-19 can distinguish among COVID-19 coughs and several types of non-COVID-19 coughs. The accuracy is promising enough to encourage a large-scale collection of labeled cough data to gauge the generalization capability of AI4COVID-19. AI4COVID-19 is not a clinical grade testing tool. Instead, it offers a screening tool deployable anytime, anywhere, by anyone. It can also be a clinical decision assistance tool used to channel clinical-testing and treatment to those who need it the most, thereby saving more lives.

Can Machine Learning Be Used to Recognize and Diagnose Coughs

Abstract: Emerging wireless technologies, such as 5G and beyond, are bringing new use cases to the forefront, one of the most prominent being machine learning empowered health care. One of the notable modern medical concerns that impose an immense worldwide health burden are respiratory infections. Since cough is an essential symptom of many respiratory infections, an automated system to screen for respiratory diseases based on raw cough data would have a multitude of beneficial research and medical applications. In literature, machine learning has already been successfully used to detect cough events in controlled environments. In this paper, we present a low complexity, automated recognition and diagnostic tool for screening respiratory infections that utilizes Convolutional Neural Networks (CNNs) to detect cough within environment audio and diagnose three potential illnesses (i.e., bronchitis, bronchiolitis and pertussis) based on their unique cough audio features. Both proposed detection and diagnosis models achieve an accuracy of over 89%, while also remaining computationally efficient. Results show that the proposed system is successfully able to detect and separate cough events from background noise. Moreover, the proposed single diagnosis model is capable of distinguishing between different illnesses without the need of separate models.

Can Machine Learning Be Used to Recognize and Diagnose Coughs

Abstract: Emerging wireless technologies, such as 5G and beyond, are bringing new use cases to the forefront, one of the most prominent being machine learning empowered health care. One of the notable modern medical concerns that impose an immense worldwide health burden are respiratory infections. Since cough is an essential symptom of many respiratory infections, an automated system to screen for respiratory diseases based on raw cough data would have a multitude of beneficial research and medical applications. In literature, machine learning has already been successfully used to detect cough events in controlled environments. In this paper, we present a low complexity, automated recognition and diagnostic tool for screening respiratory infections that utilizes Convolutional Neural Networks (CNNs) to detect cough within environment audio and diagnose three potential illnesses (i.e., bronchitis, bronchiolitis and pertussis) based on their unique cough audio features. Both proposed detection and diagnosis models achieve an accuracy of over 89%, while also remaining computationally efficient. Results show that the proposed system is successfully able to detect and separate cough events from background noise. Moreover, the proposed single diagnosis model is capable of distinguishing between different illnesses without the need of separate models.

Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal

Abstract: Objective To review and appraise the validity and usefulness of published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with covid-19, and for detecting people in the general population at increased risk of covid-19 infection or being admitted to hospital with the disease. Design Living systematic review and critical appraisal by the COVID-PRECISE (Precise Risk Estimation to optimise covid-19 Care for Infected or Suspected patients in diverse sEttings) group. Data sources PubMed and Embase through Ovid, up to 1 July 2020, supplemented with arXiv, medRxiv, and bioRxiv up to 5 May 2020. Study selection Studies that developed or validated a multivariable covid-19 related prediction model. Data extraction At least two authors independently extracted data using the CHARMS (critical appraisal and data extraction for systematic reviews of prediction modelling studies) checklist; risk of bias was assessed using PROBAST (prediction model risk of bias assessment tool). Results 37 421 titles were screened, and 169 studies describing 232 prediction models were included. The review identified seven models for identifying people at risk in the general population; 118 diagnostic models for detecting covid-19 (75 were based on medical imaging, 10 to diagnose disease severity); and 107 prognostic models for predicting mortality risk, progression to severe disease, intensive care unit admission, ventilation, intubation, or length of hospital stay. The most frequent types of predictors included in the covid-19 prediction models are vital signs, age, comorbidities, and image features. Flu-like symptoms are frequently predictive in diagnostic models, while sex, C reactive protein, and lymphocyte counts are frequent prognostic factors. Reported C index estimates from the strongest form of validation available per model ranged from 0.71 to 0.99 in prediction models for the general population, from 0.65 to more than 0.99 in diagnostic models, and from 0.54 to 0.99 in prognostic models. All models were rated at high or unclear risk of bias, mostly because of non-representative selection of control patients, exclusion of patients who had not experienced the event of interest by the end of the study, high risk of model overfitting, and unclear reporting. Many models did not include a description of the target population (n=27, 12%) or care setting (n=75, 32%), and only 11 (5%) were externally validated by a calibration plot. The Jehi diagnostic model and the 4C mortality score were identified as promising models. Conclusion Prediction models for covid-19 are quickly entering the academic literature to support medical decision making at a time when they are urgently needed. This review indicates that almost all pubished prediction models are poorly reported, and at high risk of bias such that their reported predictive performance is probably optimistic. However, we have identified two (one diagnostic and one prognostic) promising models that should soon be validated in multiple cohorts, preferably through collaborative efforts and data sharing to also allow an investigation of the stability and heterogeneity in their performance across populations and settings. Details on all reviewed models are publicly available at https://www.covprecise.org/. Methodological guidance as provided in this paper should be followed because unreliable predictions could cause more harm than benefit in guiding clinical decisions. Finally, prediction model authors should adhere to the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) reporting guideline. Systematic review registration Protocol https://osf.io/ehc47/, registration https://osf.io/wy245. Readers’ note This article is a living systematic review that will be updated to reflect emerging evidence. Updates may occur for up to two years from the date of original publication. This version is update 3 of the original article published on 7 April 2020 (BMJ 2020;369:m1328). Previous updates can be found as data supplements (https://www.bmj.com/content/369/bmj.m1328/related#datasupp). When citing this paper please consider adding the update number and date of access for clarity.

CovidGAN: Data Augmentation Using Auxiliary Classifier GAN for Improved Covid-19 Detection

Abstract: Coronavirus (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spread of COVID-19 seems to have a detrimental effect on the global economy and health. A positive chest X-ray of infected patients is a crucial step in the battle against COVID-19. Early results suggest that abnormalities exist in chest X-rays of patients suggestive of COVID-19. This has led to the introduction of a variety of deep learning systems and studies have shown that the accuracy of COVID-19 patient detection through the use of chest X-rays is strongly optimistic. Deep learning networks like convolutional neural networks (CNNs) need a substantial amount of training data. Because the outbreak is recent, it is difficult to gather a significant number of radiographic images in such a short time. Therefore, in this research, we present a method to generate synthetic chest X-ray (CXR) images by developing an Auxiliary Classifier Generative Adversarial Network (ACGAN) based model called CovidGAN. In addition, we demonstrate that the synthetic images produced from CovidGAN can be utilized to enhance the performance of CNN for COVID-19 detection. Classification using CNN alone yielded 85% accuracy. By adding synthetic images produced by CovidGAN,the accuracy increased to 95%. We hope this method will speed up COVID-19 detection and lead to more robust systems of radiology.

COVID-19 Artificial Intelligence Diagnosis Using Only Cough Recordings

Abstract: Goal: We hypothesized that COVID-19 subjects, especially including asymptomatics, could be accurately discriminated only from a forced-cough cell phone recording using Artificial Intelligence. To train our MIT Open Voice model we built a data collection pipeline of COVID-19 cough recordings through our website (opensigma.mit.edu) between April and May 2020 and created the largest audio COVID-19 cough balanced dataset reported to date with 5,320 subjects. Methods: We developed an AI speech processing framework that leverages acoustic biomarker feature extractors to pre-screen for COVID-19 from cough recordings, and provide a personalized patient saliency map to longitudinally monitor patients in real-time, non-invasively, and at essentially zero variable cost. Cough recordings are transformed with Mel Frequency Cepstral Coefficient and inputted into a Convolutional Neural Network (CNN) based architecture made up of one Poisson biomarker layer and 3 pre-trained ResNet50's in parallel, outputting a binary pre-screening diagnostic. Our CNN-based models have been trained on 4256 subjects and tested on the remaining 1064 subjects of our dataset. Transfer learning was used to learn biomarker features on larger datasets, previously successfully tested in our Lab on Alzheimer's, which significantly improves the COVID-19 discrimination accuracy of our architecture. Results: When validated with subjects diagnosed using an official test, the model achieves COVID-19 sensitivity of 98.5% with a specificity of 94.2% (AUC: 0.97). For asymptomatic subjects it achieves sensitivity of 100% with a specificity of 83.2% . Conclusions: AI techniques can produce a free, non-invasive, real-time, any-time, instantly distributable, large-scale COVID-19 asymptomatic screening tool to augment current approaches in containing the spread of COVID-19. Practical use cases could be for daily screening of students, workers, and public as schools, jobs, and transport reopen, or for pool testing to quickly alert of outbreaks in groups. General speech biomarkers may exist that cover several disease categories, as we demonstrated using the same ones for COVID-19 and Alzheimer's.

Mapping the landscape of artificial intelligence applications against COVID-19

Abstract: COVID-19, the disease caused by the SARS-CoV-2 virus, has been declared a pandemic by the World Health Organization, which has reported over 18 million confirmed cases as of August 5, 2020 In this review, we present an overview of recent studies using Machine Learning and, more broadly, Artificial Intelligence, to tackle many aspects of the COVID-19 crisis We have identified applications that address challenges posed by COVID-19 at different scales, including: molecular, by identifying new or existing drugs for treatment;clinical, by supporting diagnosis and evaluating prognosis based on medical imaging and non-invasive measures;and societal, by tracking both the epidemic and the accompanying infodemic using multiple data sources We also review datasets, tools, and resources needed to facilitate Artificial Intelligence research, and discuss strategic considerations related to the operational implementation of multidisciplinary partnerships and open science We highlight the need for international cooperation to maximize the potential of AI in this and future pandemics ©2020 AI Access Foundation All rights reserved