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Isaac M. Oderberg
Researcher at Brigham and Women's Hospital
Publications - 15
Citations - 617
Isaac M. Oderberg is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Regeneration (biology) & Planarian. The author has an hindex of 9, co-authored 12 publications receiving 477 citations. Previous affiliations of Isaac M. Oderberg include Howard Hughes Medical Institute & University of California, Los Angeles.
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Journal ArticleDOI
Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.
Kan V. Lu,Shaojun Zhu,Anna Nada Cvrljevic,Tiffany T. Huang,Shawn M. Sarkaria,David Ahkavan,Julie Dang,Eduard B. Dinca,Seema B. Plaisier,Isaac M. Oderberg,Yohan Lee,Zugen Chen,Jeremy S. Caldwell,Yongmin Xie,Joseph A. Loo,David Seligson,Arnab Chakravari,Francis Y. Lee,Roberto Weinmann,Timothy F. Cloughesy,Stanley F. Nelson,Gabriele Bergers,Thomas G. Graeber,Frank B. Furnari,C. David James,Webster K. Cavenee,Terrance Grant Johns,Paul S. Mischel +27 more
TL;DR: A mechanism linking EGFR signaling with Fyn and Src activation to promote tumor progression and invasion in vivo is established and rationale for combined anti-EGFR and anti-SFK targeted therapies is provided.
Journal ArticleDOI
Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis
Barbara G. Mellone,Kathryn J. Grive,Vladimir Shteyn,Vladimir Shteyn,Sarion R. Bowers,Isaac M. Oderberg,Isaac M. Oderberg,Gary H. Karpen,Gary H. Karpen +8 more
TL;DR: The unusual timing of CID recruitment and unique dynamics of CAL1 identify a distinctCentromere assembly pathway in Drosophila and suggest that CAL1 is a key regulator of centromere propagation.
Journal ArticleDOI
Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity
Omri Wurtzel,Omri Wurtzel,Isaac M. Oderberg,Isaac M. Oderberg,Peter W. Reddien,Peter W. Reddien +5 more
TL;DR: This work identified positional signals that activate regionalized transcriptional programs in the stem cell population and subsequently promote cell-type diversity in the epidermis and identified neoblasts that required dorsal-ventral epidermal identities and functions, in response to BMP signaling.
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foxF-1 Controls Specification of Non-body Wall Muscle and Phagocytic Cells in Planarians.
M. Lucila Scimone,Omri Wurtzel,Kathryn Malecek,Christopher T. Fincher,Isaac M. Oderberg,Kellie M. Kravarik,Peter W. Reddien +6 more
TL;DR: A regulatory program for planarian muscle cell subsets and phagocytic cells, both driven by foxF-1 is described, suggesting that FoxF regulates formation of an ancient and broadly conserved subset of mesoderm derivatives in the Bilateria.
Journal ArticleDOI
There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma.
TL;DR: Zebrafish models of HCC are reviewed and areas on which to focus future research efforts to maximize the advantages of the zebrafish model system are identified.