I
Isabel Keller
Researcher at Leibniz Institute of Marine Sciences
Publications - 18
Citations - 813
Isabel Keller is an academic researcher from Leibniz Institute of Marine Sciences. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 8, co-authored 12 publications receiving 681 citations. Previous affiliations of Isabel Keller include University of Basel & Saarland University.
Papers
More filters
Journal ArticleDOI
Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial
Silke Walter,Panagiotis Kostopoulos,Anton Haass,Isabel Keller,Martin Lesmeister,Thomas Schlechtriemen,Christian L. Roth,Panagiotis Papanagiotou,Iris Q. Grunwald,Helmut Schumacher,Stephan Helwig,Julio Viera,Heiko Körner,Maria Alexandrou,Umut Yilmaz,Karin Ziegler,K.I. Schmidt,Rainer Dabew,Darius Kubulus,Yang Liu,Thomas Volk,Kai Kronfeld,Christian Ruckes,Thomas Bertsch,Wolfgang Reith,Klaus Fassbender +25 more
TL;DR: For patients with suspected stroke, treatment by the mobile stroke unit substantially reduced median time from alarm to therapy decision, and the MSU strategy offers a potential solution to the medical problem of the arrival of most stroke patients at the hospital too late for treatment.
Journal ArticleDOI
Bringing the hospital to the patient: first treatment of stroke patients at the emergency site.
Silke Walter,Panagiotis Kostpopoulos,Anton Haass,Stefan Helwig,Isabel Keller,Tamara Licina,Thomas Schlechtriemen,Christian L. Roth,Panagiotis Papanagiotou,A. Zimmer,Julio Vierra,Heiko Körner,K.I. Schmidt,Marie Sophie Romann,Maria Alexandrou,Umut Yilmaz,Iris Q. Grunwald,Darius Kubulus,Martin Lesmeister,Stephan Ziegeler,Alexander Pattar,Martin Golinski,Yang Liu,Thomas Volk,Thomas Bertsch,Wolfgang Reith,Klaus Fassbender +26 more
TL;DR: This preliminary study proves the feasibility of guideline-adherent, etiology-specific and causal treatment of acute stroke directly at the emergency site.
Journal ArticleDOI
Point‐of‐care laboratory halves door‐to‐therapy‐decision time in acute stroke
Silke Walter,Panagiotis Kostopoulos,Anton Haass,Martin Lesmeister,Mihaela Grasu,Iris Q. Grunwald,Isabel Keller,Stephan Helwig,Carmen Becker,Juergen Geisel,Thomas Bertsch,Sarah Kaffiné,Annika Leingärtner,Panagiotis Papanagiotou,Christian L. Roth,Yang Liu,Wolfgang Reith,Klaus Fassbender +17 more
TL;DR: Results showed that reconfiguration of the entire stroke laboratory analysis to a point‐of‐care system was feasible for 200 consecutively admitted patients, and may offer a new solution for the integration of laboratory workup into routine hyperacute stroke management.
Journal ArticleDOI
Prehospital Stroke Management Optimized by Use of Clinical Scoring vs Mobile Stroke Unit for Triage of Patients With Stroke: A Randomized Clinical Trial.
Stefan Helwig,Andreas Ragoschke-Schumm,Lenka Schwindling,Michael Kettner,Safwan Roumia,Johann Kulikovski,Isabel Keller,Matthias Manitz,Daniel Martens,Daniel Grün,Silke Walter,Martin Lesmeister,Kira Ewen,Jannik Brand,Mathias Fousse,Jil Kauffmann,Valerie C. Zimmer,Shrey Mathur,Thomas Bertsch,Jürgen Guldner,Achim Magull-Seltenreich,Andreas Binder,Elmar Spüntrup,Anastasios Chatzikonstantinou,Oliver Adam,Kai Kronfeld,Yang Liu,Christian Ruckes,Helmut Schumacher,Iris Q. Grunwald,Umut Yilmaz,Thomas Schlechtriemen,Wolfgang Reith,Klaus Fassbender +33 more
TL;DR: Whereas prehospital management optimized by LAMS allows accurate triage decisions for approximately 70% of patients, MSU-based management enables accurate triages for 100% and both approaches are potentially valuable in triaging stroke patients.
Journal ArticleDOI
Hosts are ahead in a marine host-parasite coevolutionary arms race: innate immune system adaptation in pipefish Syngnathus typhle against Vibrio phylotypes
TL;DR: Pipefish plasma displays stronger antimicrobial activity against sympatric Vibrio phylotypes compared to allopatric ones, which suggests that host defense is genetically adapted against local bacteria with a broad and unspecialized host spectrum, a situation that is typical for marine systems with weak host population structure.