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Isabelle Campargue
Researcher at Ludwig Institute for Cancer Research
Publications - 2
Citations - 1068
Isabelle Campargue is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Transactivation & Bcl-2-associated X protein. The author has an hindex of 2, co-authored 2 publications receiving 1003 citations.
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ASPP proteins specifically stimulate the apoptotic function of p53.
Yardena Samuels-Lev,Daniel J. O'Connor,Daniele Bergamaschi,Giuseppe Trigiante,Jung-Kuang Hsieh,Shan Zhong,Isabelle Campargue,Louie Naumovski,Tim Crook,Xin Lu +9 more
TL;DR: The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53, therefore, ASPP regulate the tumor suppression function of p53 in vivo.
Journal ArticleDOI
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi,Yardena Samuels,Nigel J. O'Neil,Giuseppe Trigiante,Tim Crook,Jung-Kuang Hsieh,Daniel J. O'Connor,Shan Zhong,Isabelle Campargue,Matthew L. Tomlinson,Patricia E. Kuwabara,Xin Lu +11 more
TL;DR: iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis and could provide an important new strategy for treating tumors expressing wild-type p53.