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Isabelle Cleynen
Researcher at Katholieke Universiteit Leuven
Publications - 30
Citations - 6857
Isabelle Cleynen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Genome-wide association study & Inflammatory bowel disease. The author has an hindex of 17, co-authored 22 publications receiving 5822 citations. Previous affiliations of Isabelle Cleynen include Catholic University of Leuven & The Catholic University of America.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Isabelle Cleynen,Isabelle Cleynen,Gabrielle Boucher,Luke Jostins,Luke Jostins,Luke Jostins,L. Philip Schumm,Sebastian Zeissig,Tariq Ahmad,Vibeke Andersen,Jane M. Andrews,Jane M. Andrews,Vito Annese,Stephan Brand,Steven R. Brant,Judy H. Cho,Mark J. Daly,Marla Dubinsky,Richard H. Duerr,Lynnette R. Ferguson,Andre Franke,Richard B. Gearry,Richard B. Gearry,Philippe Goyette,Hakon Hakonarson,Jonas Halfvarson,Johannes R. Hov,Hailang Huang,Nicholas A. Kennedy,Limas Kupčinskas,Ian C. Lawrance,James Lee,Jack Satsangi,Stephan Schreiber,Emilie Théâtre,Andrea E. van der Meulen-de Jong,Rinse K. Weersma,David C. Wilson,David C. Wilson,Miles Parkes,Severine Vermeire,John D. Rioux,John C. Mansfield,Mark S. Silverberg,Graham L. Radford-Smith,Graham L. Radford-Smith,Dermot P.B. McGovern,Jeffrey C. Barrett,Charlie W. Lees +48 more
TL;DR: The largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.
Journal ArticleDOI
Fine-mapping inflammatory bowel disease loci to single-variant resolution
Hailiang Huang,Hailiang Huang,Ming Fang,Luke Jostins,Maša Umićević Mirkov,Gabrielle Boucher,Carl A. Anderson,Vibeke Andersen,Isabelle Cleynen,Adrian Cortes,Adrian Cortes,François Crins,Mauro D'Amato,Mauro D'Amato,Valérie Deffontaine,Julia Dmitrieva,Elisa Docampo,Mahmoud Elansary,Kyle Kai-How Farh,Kyle Kai-How Farh,Kyle Kai-How Farh,Andre Franke,Ann-Stephan Gori,Philippe Goyette,Jonas Halfvarson,Talin Haritunians,Jo Knight,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Rob Mariman,Theo Meuwissen,Myriam Mni,Yukihide Momozawa,Miles Parkes,Sarah L. Spain,Sarah L. Spain,Emilie Theatre,Gosia Trynka,Jack Satsangi,Suzanne van Sommeren,Suzanne van Sommeren,Severine Vermeire,Ramnik J. Xavier,Ramnik J. Xavier,Rinse K. Weersma,Richard H. Duerr,Christopher G Mathew,Christopher G Mathew,John D. Rioux,John D. Rioux,Dermot P.B. McGovern,Judy H. Cho,Michel Georges,Mark J. Daly,Mark J. Daly,Jeffrey C. Barrett +56 more
TL;DR: The results of this study suggest that high-resolution fine-mapping in large samples can convert many discoveries from genome-wide association studies into statistically convincing causal variants, providing a powerful substrate for experimental elucidation of disease mechanisms.
Journal ArticleDOI
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismüller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Müller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Nöthen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. König,Kristian Hveem,Isabelle Cleynen,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Björnsson,Richard Sandford,Peter R. Durie,Espen Melum,Espen Melum,Morten H. Vatn,Morten H. Vatn,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Jean-Paul Achkar,Kirsten Muri Boberg,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +95 more
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismueller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Mueller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Noethen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. Koenig,Kristian Hveem,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Bjoernsson,Richard Sandford,Peter R. Durie,Espen Melum,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +83 more
Abstract: Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.