Author
Isabelle Radford-Weiss
Other affiliations: French Institute of Health and Medical Research, Paris Descartes University
Bio: Isabelle Radford-Weiss is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 35, co-authored 80 publications receiving 3977 citations. Previous affiliations of Isabelle Radford-Weiss include French Institute of Health and Medical Research & Paris Descartes University.
Papers published on a yearly basis
Papers
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TL;DR: The clinical and biological characteristics of RCD I and RCD II at diagnosis, the risk of developing an overt lymphoma, and the predictive factors of survival were analyzed in univariate and multivariate analyses as mentioned in this paper.
321 citations
TL;DR: In this paper, the authors used morphologic, cytogenetic, and molecular analyses for optimal management of acute promyelocytic leukemia (APL) patients and better understanding of the pathogenesis of the disease.
305 citations
TL;DR: It is shown that glutamine removal inhibits mTORC1 and induces apoptosis in AML cells, and that l-ases upregulate glutamine synthase expression in leukemic cells and that a GS knockdown enhances l-ase-induced apoptotic response in someAML cells.
238 citations
Medical Research Council1, University of Southampton2, University of Kiel3, University of Navarra4, Southmead Hospital5, Katholieke Universiteit Leuven6, Great Ormond Street Hospital7, Queen Mary University of London8, French Institute of Health and Medical Research9, Necker-Enfants Malades Hospital10, Boston Children's Hospital11, University of Bath12
TL;DR: The findings implicate the CEBP gene family as novel oncogenes in BCP-ALL, and suggest opposing functions of CEBP dysregulation in myeloid and lymphoid leukemogenesis.
197 citations
TL;DR: The present study documents for the first time the existence of a characteristic cytogenetic profile for this novel disease entity, supportive of the hypothesis that CD4(+), CD56(+) DC2 acute leukemia may arise from an undifferentiated nonmyeloid nonlymphoid progenitor cell.
184 citations
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Book•
29 Sep 2017
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Abstract: WHO CLASSIFICATION OF TUMOURS OF HAEMATOPOIETIC AND LYMPHOID TISSUES , WHO CLASSIFICATION OF TUMOURS OF HAEMATOPOIETIC AND LYMPHOID TISSUES , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
13,835 citations
TL;DR: Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli, along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
Abstract: Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
2,795 citations
TL;DR: Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR.
2,687 citations
TL;DR: This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
Abstract: Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
1,921 citations
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
1,771 citations