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Isharat Yusuf
Researcher at MedImmune
Publications - 24
Citations - 3412
Isharat Yusuf is an academic researcher from MedImmune. The author has contributed to research in topics: B cell & Cellular differentiation. The author has an hindex of 14, co-authored 17 publications receiving 3099 citations. Previous affiliations of Isharat Yusuf include University of California, Irvine & La Jolla Institute for Allergy and Immunology.
Papers
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Journal ArticleDOI
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
Robert J. Johnston,Amanda C. Poholek,Daniel DiToro,Isharat Yusuf,Danelle Eto,Burton E. Barnett,Alexander L. Dent,Joe Craft,Shane Crotty,Shane Crotty +9 more
TL;DR: It is found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo TFH differentiation and T cell help to B cells in mice, and that Bcl 6 and Blimp-1 play central but opposing roles inTFH differentiation.
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IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
Danelle Eto,Christopher Lao,Daniel DiToro,Burton E. Barnett,Tania C. Escobar,Robin Kageyama,Isharat Yusuf,Shane Crotty +7 more
TL;DR: It is indicated that optimal Tfh formation requires IL-21 and IL-6, and that cytokines alone are insufficient to drive T fh differentiation.
Journal ArticleDOI
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150).
Isharat Yusuf,Robin Kageyama,Laurel A. Monticelli,Robert J. Johnston,Robert J. Johnston,Daniel DiToro,Kyle Hansen,Burton E. Barnett,Shane Crotty,Shane Crotty +9 more
TL;DR: It is demonstrated that GC-associated T follicular helper (GC TFH) cells can be identified by their coexpression of CXCR5 and the GL7 epitope, allowing for phenotypic and functional analysis of TFH and GC TFH populations.
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Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory
Youn Soo Choi,Jessica A. Yang,Isharat Yusuf,Robert J. Johnston,Robert J. Johnston,Jason A. Greenbaum,Bjoern Peters,Shane Crotty,Shane Crotty +8 more
TL;DR: The hypothesis that CD4 and CD8 T cells share core aspects of a memory cell precursor gene expression program involving Bcl6 is supported, and a strong relationship exists between Tfh cells and memory CD4 T cell development.
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Regulation of quiescence in lymphocytes
Isharat Yusuf,David A. Fruman +1 more
TL;DR: This work discusses candidate lymphocyte quiescence factors and their potential target genes and mechanisms of action, and suggests transcription factors appear to act as master regulators of gene expression patterns that enforce the quiescent phenotype.