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Israel Liberzon

Bio: Israel Liberzon is an academic researcher from University of Michigan. The author has contributed to research in topics: Prefrontal cortex & Amygdala. The author has an hindex of 80, co-authored 280 publications receiving 26492 citations. Previous affiliations of Israel Liberzon include University of Illinois at Chicago & Mental Health Services.


Papers
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Journal ArticleDOI
TL;DR: A critical comparison of findings across individual studies is provided and suggests that separate brain regions are involved in different aspects of emotion.

3,349 citations

Journal ArticleDOI
TL;DR: Additional research will be needed to clarify the exact role of each component of the fear circuitry in the anxiety disorders, determine whether functional abnormalities identified in the Anxiety disorders represent acquired signs of the disorders or vulnerability factors that increase the risk of developing them, and use functional neuroimaging to predict treatment response and assess treatment-related changes in brain function.

1,617 citations

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TL;DR: Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour.
Abstract: Contexts surround and imbue meaning to events; they are essential for recollecting the past, interpreting the present and anticipating the future. Indeed, the brain's capacity to contextualize information permits enormous cognitive and behavioural flexibility. Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour. Dysfunction in this network may be involved in several forms of psychopathology, including post-traumatic stress disorder, schizophrenia and substance abuse disorders.

1,196 citations

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TL;DR: This Review attempts to present the current state of understanding of post-traumatic stress disorder on the basis of psychophysiological, structural and functional neuroimaging, and endocrinological, genetic and molecular biological studies in humans and in animal models.
Abstract: Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is considered to be known: that is, an event that involves threat to the physical integrity of oneself or others and induces a response of intense fear, helplessness or horror. Although PTSD is still largely regarded as a psychological phenomenon, over the past three decades the growth of the biological PTSD literature has been explosive, and thousands of references now exist. Ultimately, the impact of an environmental event, such as a psychological trauma, must be understood at organic, cellular and molecular levels. This Review attempts to present the current state of this understanding on the basis of psychophysiological, structural and functional neuroimaging, and endocrinological, genetic and molecular biological studies in humans and in animal models.

1,177 citations

Journal ArticleDOI
TL;DR: It is found that males showed more lateralization of emotional activity, and females showed more brainstem activation in affective paradigms, providing evidence that lateralization in emotional activity is more complex and region-specific than predicted by previous theories of emotion and the brain.

1,118 citations


Cited by
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Journal ArticleDOI
TL;DR: The results suggest a functional architecture for the cognitive control of emotion that dovetails with findings from other human and nonhuman research on emotion.

3,817 citations

Journal ArticleDOI
TL;DR: This work reviews the emerging literature that relates social cognition to the medial frontal cortex and proposes a theoretical model of medial frontal cortical function relevant to different aspects of social cognitive processing.
Abstract: Social interaction is a cornerstone of human life, yet the neural mechanisms underlying social cognition are poorly understood. Recently, research that integrates approaches from neuroscience and social psychology has begun to shed light on these processes, and converging evidence from neuroimaging studies suggests a unique role for the medial frontal cortex. We review the emerging literature that relates social cognition to the medial frontal cortex and, on the basis of anatomical and functional characteristics of this brain region, propose a theoretical model of medial frontal cortical function relevant to different aspects of social cognitive processing.

3,426 citations

Journal ArticleDOI
TL;DR: A critical comparison of findings across individual studies is provided and suggests that separate brain regions are involved in different aspects of emotion.

3,349 citations

Journal ArticleDOI
TL;DR: It is concluded that multiple Imputation for Nonresponse in Surveys should be considered as a legitimate method for answering the question of why people do not respond to survey questions.
Abstract: 25. Multiple Imputation for Nonresponse in Surveys. By D. B. Rubin. ISBN 0 471 08705 X. Wiley, Chichester, 1987. 258 pp. £30.25.

3,216 citations