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Issei Komuro
Researcher at University of Tokyo
Publications - 1398
Citations - 52606
Issei Komuro is an academic researcher from University of Tokyo. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 101, co-authored 1266 publications receiving 46138 citations. Previous affiliations of Issei Komuro include Japan Agency for Medical Research and Development & Beth Israel Deaconess Medical Center.
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The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2014)
Kazuaki Shimamoto,Katsuyuki Ando,Toshiro Fujita,Naoyuki Hasebe,Jitsuo Higaki,Masatsugu Horiuchi,Yutaka Imai,Tsutomu Imaizumi,Toshihiko Ishimitsu,Masaaki Ito,Sadayoshi Ito,Hiroshi Itoh,Hiroshi Iwao,Hisashi Kai,Kazuomi Kario,Naok Kashihara,Yuhei Kawano,Shokei Kim-Mitsuyama,Genjiro Kimura,Katsuhiko Kohara,Issei Komuro,Hiroo Kumagai,Hideo Matsuura,Katsuyuki Miura,Ryuichi Morishita,Mitsuhide Naruse,Koichi Node,Yusuke Ohya,Hiromi Rakugi,Ikuo Saito,Shigeyuki Saitoh,Kazuyuki Shimada,Tatsuo Shimosawa,Hiromichi Suzuki,Kouichi Tamura,Norio Tanahashi,Takuya Tsuchihashi,Makoto Uchiyama,Shinichiro Ueda,Satoshi Umemura +39 more
TL;DR: Kazuaki SHIMAMOTO, Katsuyuki ANDO, Toshiro FUJITA, Naoyuki HASEBE, Jitsuo HIGAKI, Masatsugu HORIUCHI, Yutaka IMAI, Tsutomu IMAIZUMI, Toshihiko ISHIMITSU, Masaaki ITO, Sadayoshi ITO and Hiroshi ITOH are presented.
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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Takafumi Oka,Shungo Hikoso,Osamu Yamaguchi,Manabu Taneike,Manabu Taneike,Toshihiro Takeda,Takahito Tamai,Jota Oyabu,Tomokazu Murakawa,Hiroyuki Nakayama,Kazuhiko Nishida,Kazuhiko Nishida,Shizuo Akira,Akitsugu Yamamoto,Issei Komuro,Kinya Otsu,Kinya Otsu +16 more
TL;DR: It is shown that mitochondrial DNA that escapes from autophagy cell-autonomously leads to Toll-like receptor (TLR) 9-mediated inflammatory responses in cardiomyocytes and is capable of inducing myocarditis and dilated cardiopathy in DNase II-deficient mice.
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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.
TL;DR: Vascular endothelial cells with senescence-associated phenotypes are present in human atherosclerotic lesions, and endothelial cellsenescence induced by telomere shortening may contribute to atherogenesis.
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p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Masanori Sano,Tohru Minamino,Haruhiro Toko,Hideyuki Miyauchi,Masayuki Orimo,Yingjie Qin,Hiroshi Akazawa,Kaoru Tateno,Yosuke Kayama,Mutsuo Harada,Ippei Shimizu,Takayuki Asahara,Hirofumi Hamada,Shuhei Tomita,Jeffrey D. Molkentin,Yunzeng Zou,Issei Komuro +16 more
TL;DR: It is shown that cardiac angiogenesis is crucially involved in the adaptive mechanism of cardiachypertrophy and that p53 accumulation is essential for the transition from cardiac hypertrophy to heart failure and that the anti-angiogenic property of p53 may have a crucial function in the transition.
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Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.
TL;DR: This work has shown that a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells and stimulated the DNA synthesis of VSMCs in a dose‐dependent manner, which might be related to the development of atherosclerosis.