Ivan Nenchev

Bio: Ivan Nenchev is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Schizoaffective disorder & Diagnosis of schizophrenia. The author has an hindex of 2, co-authored 3 publications receiving 14 citations.

Coherence models in schizophrenia

Abstract: Incoherent discourse in schizophrenia has long been recognized as a dominant symptom of the mental disorder (Bleuler, 1911/1950). Recent studies have used modern sentence and word embeddings to compute coherence metrics for spontaneous speech in schizophrenia. While clinical ratings always have a subjective element, computational linguistic methodology allows quantification of speech abnormalities. Clinical and empirical knowledge from psychiatry provide the theoretical and conceptual basis for modelling. Our study is an interdisciplinary attempt at improving coherence models in schizophrenia. Speech samples were obtained from healthy controls and patients with a diagnosis of schizophrenia or schizoaffective disorder and different severity of positive formal thought disorder. Interviews were transcribed and coherence metrics derived from different embeddings. One model found higher coherence metrics for controls than patients. All other models remained non-significant. More detailed analysis of the data motivates different approaches to improving coherence models in schizophrenia, e.g. by assessing referential abnormalities.

Modeling Incoherent Discourse in Non-Affective Psychosis.

Abstract: Background Computational linguistic methodology allows quantification of speech abnormalities in non-affective psychosis. For this patient group, incoherent speech has long been described as a symptom of formal thought disorder. Our study is an interdisciplinary attempt at developing a model of incoherence in non-affective psychosis, informed by computational linguistic methodology as well as psychiatric research, which both conceptualize incoherence as associative loosening. The primary aim of this pilot study was methodological: to validate the model against clinical data and reduce bias in automated coherence analysis. Methods Speech samples were obtained from patients with a diagnosis of schizophrenia or schizoaffective disorder, who were divided into two groups of n = 20 subjects each, based on different clinical ratings of positive formal thought disorder, and n = 20 healthy control subjects. Results Coherence metrics that were automatically derived from interview transcripts significantly predicted clinical ratings of thought disorder. Significant results from multinomial regression analysis revealed that group membership (controls vs. patients with vs. without formal thought disorder) could be predicted based on automated coherence analysis when bias was considered. Further improvement of the regression model was reached by including variables that psychiatric research has shown to inform clinical diagnostics of positive formal thought disorder. Conclusions Automated coherence analysis may capture different features of incoherent speech than clinical ratings of formal thought disorder. Models of incoherence in non-affective psychosis should include automatically derived coherence metrics as well as lexical and syntactic features that influence the comprehensibility of speech.

Understanding Language Abnormalities and Associated Clinical Markers in Psychosis: The Promise of Computational Methods.

Abstract: The language and speech of individuals with psychosis reflect their impairments in cognition and motor processes. These language disturbances can be used to identify individuals with and at high risk for psychosis, as well as help track and predict symptom progression, allowing for early intervention and improved outcomes. However, current methods of language assessment-manual annotations and/or clinical rating scales-are time intensive, expensive, subject to bias, and difficult to administer on a wide scale, limiting this area from reaching its full potential. Computational methods that can automatically perform linguistic analysis have started to be applied to this problem and could drastically improve our ability to use linguistic information clinically. In this article, we first review how these automated, computational methods work and how they have been applied to the field of psychosis. We show that across domains, these methods have captured differences between individuals with psychosis and healthy controls and can classify individuals with high accuracies, demonstrating the promise of these methods. We then consider the obstacles that need to be overcome before these methods can play a significant role in the clinical process and provide suggestions for how the field should address them. In particular, while much of the work thus far has focused on demonstrating the successes of these methods, we argue that a better understanding of when and why these models fail will be crucial toward ensuring these methods reach their potential in the field of psychosis.

Do Models of Mental Health Based on Social Media Data Generalize

Abstract: Proxy-based methods for annotating mental health status in social media have grown popular in computational research due to their ability to gather large training samples. However, an emerging body of literature has raised new concerns regarding the validity of these types of methods for use in clinical applications. To further understand the robustness of distantly supervised mental health models, we explore the generalization ability of machine learning classifiers trained to detect depression in individuals across multiple social media platforms. Our experiments not only reveal that substantial loss occurs when transferring between platforms, but also that there exist several unreliable confounding factors that may enable researchers to overestimate classification performance. Based on these results, we enumerate recommendations for future mental health dataset construction.