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Ivan Tarassov
Researcher at University of Strasbourg
Publications - 67
Citations - 3087
Ivan Tarassov is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Mitochondrion & Transfer RNA. The author has an hindex of 29, co-authored 66 publications receiving 2818 citations. Previous affiliations of Ivan Tarassov include Centre national de la recherche scientifique & Moscow State University.
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Deleterious Mutation in the Mitochondrial Arginyl-Transfer RNA Synthetase Gene Is Associated with Pontocerebellar Hypoplasia
Simon Edvardson,Avraham Shaag,Olga Kolesnikova,John M. Gomori,Ivan Tarassov,Tom Einbinder,Ann Saada,Orly Elpeleg +7 more
TL;DR: It is speculated that missplicing mutations in mitochondrial aminoacyl-tRNA synthethase genes preferentially affect the brain because of a tissue-specific vulnerability of the splicing machinery.
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Acute Infantile Liver Failure Due to Mutations in the TRMU Gene
Avraham Zeharia,Avraham Shaag,Orit Pappo,Anne-Marie Mager-Heckel,Ann Saada,Marine Beinat,Olga Karicheva,Hanna Mandel,Noa Ofek,Reeval Segel,Daphna Marom,Agnès Rötig,Ivan Tarassov,Orly Elpeleg +13 more
TL;DR: There is a window of time whereby patients with TRMU mutations are at increased risk of developing liver failure, and it is proposed that sulfur is a TRMU substrate and its availability is limited during the neonatal period.
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A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae
Nina Entelis,Irina Brandina,Piotr Kamenski,Igor A. Krasheninnikov,Robert P. Martin,Ivan Tarassov +5 more
TL;DR: The results indicate an alternative molecular chaperone function of glycolytic enzyme enolase in tRNA mitochondrial targeting, and propose a model suggesting that the cell exploits mitochondrial targeting of the enol enzyme in order to address the tRNA toward peri-mitochondrially synthesized preMsk1p.
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Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells
Olga Kolesnikova,Nina Entelis,Clarisse Jacquin-Becker,Francine Goltzene,Zofia M.A. Chrzanowska-Lightowlers,Robert N. Lightowlers,Robert P. Martin,Ivan Tarassov +7 more
TL;DR: These findings prove for the first time the functionality of imported tRNAs in human mitochondria in vivo and highlight the potential for exploiting the RNA import pathway to treat patients with mtDNA diseases.
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Suppression of Mutations in Mitochondrial DNA by tRNAs Imported from the Cytoplasm
Olga Kolesnikova,Nina S. Entelis,Nina S. Entelis,Hakim Mireau,Thomas D. Fox,Robert P. Martin,Ivan Tarassov +6 more
TL;DR: It is shown that cytoplasmic tRNAs with altered aminoacylation identity can be specifically targeted to the mitochondria and participate in mitochondrial translation and that human mitochondria are able to internalize yeast tRNA derivatives in vitro and that this import requires an essential yeast import factor.