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Ivor S. Douglas
Researcher at University of Colorado Denver
Publications - 156
Citations - 25369
Ivor S. Douglas is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Lung injury & Mechanical ventilation. The author has an hindex of 44, co-authored 141 publications receiving 22842 citations. Previous affiliations of Ivor S. Douglas include Anschutz Medical Campus & Hospital Authority.
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Journal ArticleDOI
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
R. P. Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +21 more
TL;DR: An update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008 is provided.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
R. Phillip Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Sean R. Townsend,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +22 more
TL;DR: A consensus committee of 68 international experts representing 30 international organizations was convened in 2008 to provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock".
Journal ArticleDOI
Drotrecogin alfa (activated) in adults with septic shock
V. Marco Ranieri,B. Taylor Thompson,Philip S. Barie,Jean-François Dhainaut,Ivor S. Douglas,Simon Finfer,Simon Finfer,Bengt Gårdlund,John C. Marshall,Andrew Rhodes,Antonio Artigas,Didier Payen,Jyrki Tenhunen,Hussein R. Al-Khalidi,Vivian P. Thompson,Jonathan Janes,William L. Macias,Burkhard Vangerow,Mark D. Williams +18 more
TL;DR: DrotAA did not significantly reduce mortality at 28 or 90 days, as compared with placebo, in patients with septic shock, and rates of death at 28 and 90 days were not significantly different in other predefined subgroups, including patients at increased risk for death.
Journal ArticleDOI
Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia.
Ivan O. Rosas,Norbert Bräu,Norbert Bräu,Michael F. Waters,Ronaldo C. Go,Bradley D Hunter,Sanjay Bhagani,Daniel Skiest,Mariam Aziz,Nichola Cooper,Ivor S. Douglas,Sinisa Savic,Taryn Youngstein,Lorenzo Del Sorbo,Antonio Cubillo Gracian,David J. De La Zerda,Andrew Ustianowski,Min Bao,Sophie Dimonaco,Emily Graham,Balpreet Matharu,Helen Spotswood,Larry Tsai,Atul Malhotra +23 more
TL;DR: In this paper, a randomized trial involving hospitalized patients with severe Covid-19 pneumonia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days.
Journal ArticleDOI
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis
Eric P. Schmidt,Yimu Yang,William J. Janssen,Aneta Gandjeva,Mario J. Perez,Lea Barthel,Rachel L. Zemans,Joel Bowman,Dan Koyanagi,Zulma X. Yunt,Lynelle P. Smith,Sara S Cheng,Katherine H. Overdier,Kathy R. Thompson,Mark W. Geraci,Ivor S. Douglas,David B. Pearse,Rubin M. Tuder +17 more
TL;DR: Using intravital microscopy, it is found that endotoxemia in mice rapidly induced pulmonary microvascular glycocalyx degradation via tumor necrosis factor-α (TNF-α)-dependent mechanisms, which attenuated sepsis-induced ALI and mortality in mice.