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Izydor Apostol

Researcher at Amgen

Publications -  47
Citations -  2222

Izydor Apostol is an academic researcher from Amgen. The author has contributed to research in topics: Hemoglobin & Recombinant DNA. The author has an hindex of 22, co-authored 46 publications receiving 2111 citations. Previous affiliations of Izydor Apostol include Purdue University & Baxter International.

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Rapid Stimulation of an Oxidative Burst during Elicitation of Cultured Plant Cells: Role in Defense and Signal Transduction

TL;DR: The results suggest that H(2)O(2), implicated as a second messenger of hormone-stimulated metabolic changes in some animal cells, also plays an important role in inducing subsequent defense responses such as phytoalexin production.
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Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

TL;DR: The results confirm previously published observations for IgG1 that two analogous solvent‐exposed methionine residues in IgG2, Met 252 and Met 428, oxidize more readily than the other methions, and shows that Protein A may serve as a convenient and inexpensive surrogate for FcRn binding measurements.
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Binding of amino acid side-chains to S1 cavities of serine proteinases

TL;DR: All 20 coded P1 variants of one such inhibitor, turkey ovomucoid third domain, are obtained by recombinant DNA technology and the Pearson pro duct moment correlations for all the 15 enzyme pairs were calculated, suggesting that these may serve as a quantitative description of the specificity of the enzymes at P1.
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Incorporation of norvaline at leucine positions in recombinant human hemoglobin expressed in Escherichia coli.

TL;DR: It is reported here a novel finding that norvaline can be incorporated in place of leucine in recombinant human hemoglobin expressed in Escherichia coli, and it appears that substitution is distributed across both the β- and di-α-globins in purified recombinant hemoglobin.