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J. C. Wagner

Bio: J. C. Wagner is an academic researcher. The author has contributed to research in topics: Mesothelioma & Asbestos. The author has an hindex of 2, co-authored 2 publications receiving 1832 citations.

Papers
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Journal ArticleDOI
TL;DR: In a majority of cases of diffuse pleural mesothelioma, all but one have a probable exposure to crocidolite asbestos (Cape blue) in the Asbestos Hills which lie to the west of Kimberley in the north west of Cape Province.
Abstract: Primary malignant tumours of the pleura are uncommon Thirty-three cases (22 males, 11 females, ages 31 to 68) of diffuse pleural mesothelioma are described; all but one have a probable exposure to crocidolite asbestos (Cape blue) In a majority this exposure was in the Asbestos Hills which lie to the west of Kimberley in the north west of Cape Province The tumour is rarely seen elsewhere in South Africa

1,598 citations

Journal ArticleDOI
TL;DR: During the past five years, with the exception of the present series, no neoplasm of this nature has been diagnosed amongst 10,000 lungs examined at the Pneumoconiosis Bureau in South Africa.
Abstract: Mesothelioma of the pleura is regarded as an uncommon tumour. In the last four years we have seen 33 histologically proven cases; 28 of these had some association with the Cape asbestos field and four cases had been exposed to asbestos in industry. The tumour is rarely encountered elsewhere in South Africa. During the past five years, with the exception of the present series, no neoplasm of this nature has been diagnosed amongst 10,000 lungs examined at the Pneumoconiosis Bureau in

282 citations


Cited by
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Journal ArticleDOI
TL;DR: The authors review advances made in the past 5 to 10 years in the understanding, diagnosis, and management of mesothelioma.
Abstract: Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and the peritoneum. This tumor was once rare, but its incidence is increasing worldwide, probably as a result of widespread exposure to asbestos, a factor with which it is associated. The authors review advances made in the past 5 to 10 years in the understanding, diagnosis, and management of mesothelioma.

1,004 citations

Journal ArticleDOI
19 Jan 1990-Science
TL;DR: Available data do not support the concept that low-level exposure to asbestos is a health hazard in buildings and schools, and the concentration of asbestos fibers in air, type of asbestos, and size of fibers must be considered in evaluation of potential health risks.
Abstract: Asbestos is a commercial term for a group of fibrous minerals often associated with the development of pulmonary interstitial fibrosis (asbestosis), lung cancer, and malignant mesothelioma in occupationally exposed individuals. The pathogenicity of different forms of asbestos varies--long, thin amphibole fibers are most pathogenic, particularly in the induction of mesothelioma. Available data do not support the concept that low-level exposure to asbestos is a health hazard in buildings and schools. The concentration of asbestos fibers in air, type of asbestos, and size of fibers must be considered in evaluation of potential health risks.

690 citations

Journal ArticleDOI
01 Jun 1981-Cancer
TL;DR: Solitary fibrous tumors of the pleura are not associated with asbestos and nuclear pleomorphism and a high mitotic rate are seen in larger tumors but do not necessarily indicate a poor prognosis if the tumor is circumscribed.
Abstract: Three-hundred-sixty cases of solitary fibrous tumor of the pleura from the literature are analyzed, and eight new cases are described. Of patients reported on prior to 1972, 72% had symptoms due to the tumor at the time of diagnosis, but only 54% of patients reported on since then were symptomatic. This probably reflects earlier diagnosis as a result of increased use of chest radiographs in asymptomatic populations. Cough, chest pain, dyspnea, and/or pulmonary osteoarthropathy are each found in at least one-third of patients who have symptoms. Approximately 80% of solitary fibrous tumors of the pleura originate in the visceral and 20% in the parietal pleura. In the literature and in this experience these tumors are on the whole circumscribed. They range in size from 1–36 cm with a mean of 6 cm. Many are pedunculated on pleural-based pedicles that contain hypertrophic arteries and veins. Histologic examination of the tumor usually discloses cellular areas alternating with hyalinized and/or necrotic areas. Spindle-shaped cells typically have minimal nuclear pleomorphism and rare or absent mitoses. Numerous thin-walled vessels constitute an additional feature of large tumors. Electron microscopical examination reveals features of both fibroblasts and mesothelial cells. Solitary fibrous tumors behave in a benign fashion in 88% of cases after surgical resection. In 12% of the cases the tumor is responsible for the patient's death because of its extensive intrathoracic growth, by virtue of either late diagnosis or unresectable recurrence. No single histologic feature allows a definite prognosis. The best indicator of a good prognosis is the presence of a pedicle supporting the tumor. Also favorable is circumscription of the tumor without invasion of lung, mediastinum, or chest wall. Nuclear pleomorphism and a high mitotic rate are seen in larger tumors but do not necessarily indicate a poor prognosis if the tumor is circumscribed. Solitary fibrous tumors of the pleura are not associated with asbestos.

687 citations

Journal ArticleDOI
Julian Peto1
17 May 2001-Nature
TL;DR: The remarkable advances in cell and molecular biology over the past two decades have transformed the scope and methods of cancer epidemiology, and modern epidemiological studies often depend on genetic, biochemical or viral assays that had not been developed 20 years ago.
Abstract: By the early 1980s, epidemiologists had identified many important causes of cancer. They had also proposed the 'multi-stage' model of cancer, although none of the hypothesized events in human carcinogenesis had then been identified. The remarkable advances in cell and molecular biology over the past two decades have transformed the scope and methods of cancer epidemiology. There have been a few new discoveries based purely on traditional methods, and many long-suspected minor risks have been estimated more precisely. But modern epidemiological studies often depend on genetic, biochemical or viral assays that had not been developed 20 years ago.

637 citations