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J. Costa Pessoa

Bio: J. Costa Pessoa is an academic researcher from Instituto Superior Técnico. The author has contributed to research in topics: Circular dichroism & Potentiometric titration. The author has an hindex of 21, co-authored 37 publications receiving 1335 citations. Previous affiliations of J. Costa Pessoa include Technical University of Lisbon & University of Wales.

Papers
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Journal ArticleDOI
TL;DR: It is concluded that vanadium compounds are mainly transported in blood by transferrin, but that no study has properly addressed the influence of albumin and transferrin in the vanadium uptake by cells.
Abstract: Low molecular weight and high molecular weight metal ion binders present in blood plasma are shortly described. The binding of vanadium and ruthenium complexes by these components has received much attention, namely their interactions with human serum albumin and transferrin, and these studies are critically reviewed. The influence of the protein binding on the bioavailability of the prospective drugs, namely on the transport by blood plasma and uptake by cells is also discussed. It is concluded that vanadium compounds are mainly transported in blood by transferrin, but that no study has properly addressed the influence of albumin and transferrin in the vanadium uptake by cells. Ruthenium complexes bind strongly to HSA, most likely at the level of His residues, leading to the formation of stable adducts. If the kinetics of binding to this protein is fast enough, probably they are mainly transported by this serum protein. Nevertheless, at least for a few Ru III -complexes, hTf seems to play an active role in the uptake of ruthenium, while HSA may provide selectivity and higher activity for the compounds due to an enhanced permeability effect.

179 citations

Journal ArticleDOI
TL;DR: In this article, a review mainly discusses the immobilization strategies that have been used for vanadium complexes, typically mesoporous material, zeolites and polymers, the characterization procedures for the obtained materials, and their catalytic applications.

158 citations

Journal ArticleDOI
TL;DR: The relevance of vanadium in biological systems is known for many years and vanadium-based catalysts have important industrial applications, however, until the beginning of the 80s research on vanadium chemistry and biochemistry did not receive much attention from the scientific community.

115 citations

Journal ArticleDOI
TL;DR: A range of mostly new oxovanadium(IV) complexes are described in this paper, which contain coordinated Schiff bases, made from natural amino acids (glycine, alanine, valine, leucine, isoleucine and methionine, phenylalanine, threonine, aspartic acid, and histidine) and salicylaldehyde or such derivatives as 3-, 4-, or 5-methoxy-salicyl-aldehyde.

85 citations

Journal ArticleDOI
15 Jun 2005-Talanta
TL;DR: It is demonstrated that successful extraction and quantification of PAHs from sediments can be done with low sample mass, low reagent volume, short sonication time, short reagent time and low sonication amplitude, as compared with the values obtained after soxhlet extraction.

72 citations


Cited by
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Journal ArticleDOI
TL;DR: Aqueous V(III) Chemistry 877 6.2.1.
Abstract: 6.1.2. Aqueous V(III) Chemistry 877 6.1.3. Oxidation State of Vanadium in Tunicates 878 6.1.4. Uptake of Vanadate into Tunicates 879 6.1.5. Vanadium Binding Proteins: Vanabins 879 6.1.6. Model Complexes and Their Chemistry 880 6.1.7. Catechol-Based Model Chemistry 880 6.1.8. Vanadium Sulfate Complexes 881 6.2. Fan Worm Pseudopotamilla occelata 883 7. Vanadium Nitrogenase 883 7.1. Nitrogenases 883 7.2. Biochemistry of Nitrogenase 884 7.3. Clusters in Nitrogenase and Model Systems: Structure and Reactivity 885

1,184 citations

01 Jan 2008
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
Abstract: Triggered by the resounding success of cisplatin, the past decades have seen tremendous efforts to produce clinically beneficial analogues. The recent achievement of oxaliplatin for the treatment of colon cancer should, however, not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs. Strategies opening up new avenues are increasingly being sought using complexes of metals other than platinum such as ruthenium or gallium. Based on the chemical differences between these metals, the spectrum of molecular mechanisms of action and potential indications can be broadened substantially. Other approaches focus on complexes with tumour-targeting properties, thereby maximizing the impact on cancer cells and minimizing the problem of adverse side effects, and complexes with biologically active ligands.

698 citations

BookDOI
01 Jan 1973

430 citations

Journal ArticleDOI
TL;DR: This work reviews the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications and concludes that the potential ofVanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compound for e.g. antitumor and anti-parasitic related diseases remain promising.

373 citations

Journal ArticleDOI
TL;DR: The thorough understanding of metal binding properties of serum albumin, including the competition of various metal ions for specific binding sites is important for biomedical issues, such as new disease markers and design of metal-based drugs.

355 citations