J
J. E. Mackie
Publications - 1
Citations - 3030
J. E. Mackie is an academic researcher. The author has contributed to research in topics: Gene & Complementary DNA. The author has an hindex of 1, co-authored 1 publications receiving 2970 citations.
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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Susan P.C. Cole,Gabu Bhardwaj,James H. Gerlach,J. E. Mackie,Caroline E. Grant,Kurt C. Almquist,Alistair J. Stewart,Ebba U. Kurz,A. M. V. Duncan,Roger G. Deeley +9 more
TL;DR: Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.