J
J.E. Olley
Researcher at University of Bradford
Publications - 12
Citations - 870
J.E. Olley is an academic researcher from University of Bradford. The author has contributed to research in topics: Catalepsy & Haloperidol. The author has an hindex of 12, co-authored 12 publications receiving 867 citations.
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Journal ArticleDOI
Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of rat brain.
TL;DR: Bilateral injection of atropine into the caudate-putamen and globus pallidus did not modify the catalepsy induced by peripheral administration of haloperidol or arecoline but intranigral atropines markedly potentiated the cataleptic effects of these drugs.
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Cholinergic- and neuroleptic-induced catalepsy: modification by lesions in the caudate-putamen.
Brenda Costall,J.E. Olley +1 more
TL;DR: Both haloperidol and arecoline induced a cataleptic state in rats and a marked synergistic effect was observed upon combination of threshold doses of these two drugs, with possible role of the extrapyramidal system.
Journal ArticleDOI
The substantia nigra and stereotyped behaviour.
TL;DR: It is suggested that apomorphine stereotypy is not mediated via a direct action upon the dopamine receptor, but requires an effective nigro-striatal dopaminergic system and the mechanism involved in spontaneous stereotypy are not the same as those of the drug-induced state.
Journal ArticleDOI
Modification of the behavioural changes induced by amphetamine in the rat by lesions in the caudate nucleus, the caudate-putamen and globus pallidus
Robert J. Naylor,J.E. Olley +1 more
TL;DR: The effects of the various lesions on stereotypy and locomotor activity differentiate between these two aspects of behaviour induced by amphetamine and suggest that different anatomical sites of action may be involved.
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Stereotypic and anticataleptic activities of amphetamine after intracerebral injections
TL;DR: Results indicate the involvement of neuronal systems in both the striatum and pallidum with the production of amphetamine stereotypy and its inhibition by neuroleptic and cholinergic agents.