J. Graeme Hodgson

TL;DR: A robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes is described and multidimensional genomic data is integrated to establish patterns of somatic mutations and DNA copy number.

TL;DR: The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM) and proposed a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes as discussed by the authors.

TL;DR: Results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability.

TL;DR: Investigation of the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells suggests that targeted delivery of microRNA-124 and/or micro RNA-137 to gliobeasts tumor cells may be therapeutically efficacious for the treatment of this disease.

TL;DR: It is shown that “senescent” mouse fibroblasts, which arrested growth after repeated passage under standard culture conditions, do not express a human-like SASP, and differ from similarly cultured human cells in other respects, but when cultured in physiological oxygen and induced to senesce by radiation, mouse cells more closely resemble human cells, including expression of a robust SASP.