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J. H. Schuurmans Stekhoven

Bio: J. H. Schuurmans Stekhoven is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Pulmonary Diffusing Capacity & Breathing. The author has an hindex of 10, co-authored 14 publications receiving 714 citations.

Papers
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Journal ArticleDOI
TL;DR: To assess the potential of breast-conserving treatment for ductal carcinoma in situ (DCIS), 82 mastectomy specimens were studied by Egan's serial subgross method and found adequate excision of many DCIS will require a wide excision involving up to a whole quadrant.

561 citations

Journal ArticleDOI
TL;DR: Lymphocytes of the peripheral blood of 31 patients with juvenile amaurotic idiocy (juvenile form of ceroid lipofuscinosis) were examined with the electron microscope, and intracytoplasmic clear vacuoles were present, containing round hollow, fingerprint and highly electron dense structures.
Abstract: Lymphocytes of the peripheral blood of 31 patients with juvenile amaurotic idiocy (juvenile form of ceroid lipofuscinosis) were examined with the electron microscope. In all cases, intracytoplasmic clear vacuoles were present, containing round hollow, fingerprint and highly electron dense structures. The combination of these structures, not necessarily in one and the same vacuole, was considered to be highly indicative for the diagnosis of juvenile amaurotic idiocy. In addition to these three structures, parallel tubular inclusion bodies, rectilinear profiles and rodshaped structures were found but in a number of the cases. The parallel tubular inclusion bodies were not regarded as having any diagnostic significance.

24 citations

Journal ArticleDOI
TL;DR: A third family affected with ichthyosis bullosa of Siemens is reported, and the clinical spectrum of this mild type of epidermolytic hyperkeratosis is delineated, with the main characteristic sites being the joints, the shins and the periumbilical region.
Abstract: We report a third family affected with ichthyosis bullosa of Siemens, and we further delineate the clinical spectrum of this mild type of epidermolytic hyperkeratosis. Erythroderma had never been present in any of the affected individuals. All of them exhibited a brownish, rimpled hyperkeratosis, the main characteristic sites being the joints, the shins and the periumbilical region. Blistering occurred after slight mechanical trauma and even after sweating, resulting in superficially denuded areas. Two affected family members also suffered from chronic, relapsing pustular eruptions surrounded by a transient erythematous flare. Light- and electron-microscopic examination revealed epidermolytic hyperkeratosis limited to the upper part of the epidermis. The pustular lesions were found to be subcorneal blisters filled with neutrophils. Ichthyosis bullosa of Siemens can be clearly distinguished from bullous ichthyosiform erythroderma. The observation of subcorneal pustular dermatosis occurring in this phenotype provides further evidence for the genetic heterogeneity of epidermolytic hyperkeratosis.

23 citations

Journal ArticleDOI
TL;DR: Light-, electron microscopic and enzyme histochemical examinations (phosphorylase, LDH, NADH:TR, SDH and 3-HBDH) were performed on endomyocardial biopsies of 26 patients with heart diseases of unknown etiology and several pathologic alterations did, nonetheless, appear to have a certain prognostic value such as endocardial and interstitial fibrosis, myofibrillolysis, myolysis

16 citations

Journal ArticleDOI
TL;DR: Overall distribution of protein kinase C activity (PKC) between cytosol and membrane, in resting as well as in activated thrombocytes from Alzheimer patients, was similar to that in the control groups.

15 citations


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BookDOI
01 Jan 2013
TL;DR: The present supplements to the fourth edition of the European guidelines for quality assurance in breast cancer screening and diagnosis lay a cornerstone for a new, completely revised fifth editions of the guidelines.
Abstract: The fourth edition of the European guidelines for quality assurance in breast cancer screening and diagnosis was published by the European Commission in 2006. The present supplements to the fourth edition have been produced by the same groups of experts originally established under the Europe Against Cancer programme that have developed and updated the guidelines since the early 1990s. Over the years, the scope and the depth of the multidisciplinary guidelines have expanded, and recommendations and protocols have been updated to keep pace with developments in the field. The present supplements lay a cornerstone for a new, completely revised fifth edition of the guidelines

1,333 citations

Journal ArticleDOI
TL;DR: Progress in the understanding, pathogenesis, and treatment of ductal carcinoma in situ is summarized.
Abstract: Ductal carcinoma in situ of the breast (also called intraductal carcinoma), a clonal proliferation of malignant-appearing cells within the mammary duct lumens without evidence of invasion beyond the epithelial basement membrane, is the precursor lesion of invasive breast cancer In the past 20 years, concomitant with the wide use of screening mammography, its detected incidence has risen dramatically Data from large cohort studies and randomized trials have emerged to guide treatment This review summarizes progress in the understanding, pathogenesis, and treatment of ductal carcinoma in situ

720 citations

Journal ArticleDOI
15 Apr 2003-Cancer
TL;DR: The International Agency for Research on Cancer conducts a programme of research concentrating particularly on the epidemiology of cancer and the study of potential carcinogens in the human environment.
Abstract: The International Agency for Research on Cancer (IARC) was established in 1965 by the World Health Assembly, as an independently funded organisation within the framework of the World Health Organization. The headquarters of the Agency are in Lyon, France. The Agency conducts a programme of research concentrating particularly on the epidemiology of cancer and the study of potential carcinogens in the human environment. Its field studies are supplemented by biological and chemical research carried out in the Agency's laboratories in Lyon and, through collaborative research agreements, in national research institutions in many countries. The Agency also conducts a programme for the education and training of personnel for cancer research. The publications of the Agency contribute to the dissemination of authoritative information on different aspects of cancer research. Information about IARC publications, and how to order them, is available via the Internet at: http:// The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The authors alone are responsible for the views expressed in this publication.

718 citations

Journal Article
TL;DR: The multidisciplinary editorial board has prepared a summary document to provide an overview of the fundamental points and principles that should support any quality screening or diagnostic service.
Abstract: Rak piersi jest najczestszą przyczyna zgonu wśrod kobiet i stanowi istotny problem kliniczny. Wczesne wykrycie raka piersi dzieki regularnie prowadzonym badaniom przesiewowym za pomocą mammografii umozliwia rozpoznanie choroby w stadium, w ktorym leczenie jest skuteczniejsze i zazwyczaj wiąze sie z lepszą jakością zycia. Jednakze mammografia moze byc przyczyną niepotrzebnego stresu, dolegliwości, kosztow finansowych oraz narazenia na promieniowanie jonizujące. Z tego powodu nalezy polozyc mozliwie najwiekszy nacisk na kontrole jakości. Opracowanie Europejskich zalecen dotyczących kontroli jakości badan przesiewowych i rozpoznawania raka piersi bylo inicjatywą programu Europa przeciwko rakowi . Czwartą edycje interdyscyplinarnych zalecen opublikowano w 2006 roku. Sklada sie z okolo 400 stron podzielonych na 12 rozdzialow przygotowanych przez ponad 200 autorow i wspolautorow. Interdyscyplinarna rada wydawnicza przygotowala streszczenie dokumentu w celu przedstawienia podstawowych zasad i zalozen, na ktorych powinny opierac sie badania przesiewowe oraz diagnostyka raka piersi. Opracowanie zawiera takze tabele podsumowującą wskaźniki wydajności, aby szersze grono naukowcow moglo sie z nią zapoznac.

713 citations