J
J. Hirshfield
Researcher at United States Military Academy
Publications - 6
Citations - 1563
J. Hirshfield is an academic researcher from United States Military Academy. The author has contributed to research in topics: Receptor & Cholecystokinin. The author has an hindex of 4, co-authored 6 publications receiving 1462 citations.
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Journal ArticleDOI
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: 3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described, and the method of development of these compounds is discussed in terms of its relevance to the general problem of drug discovery.
Journal ArticleDOI
Methods for Drug Discovery: Development of Potent, Selective, Orally Effective Cholecystokinin Antagonists.
Ben E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,George F. Lundell,Daniel F. Veber,Paul S. Anderson,Raymond S.L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,Paul J. Kling,K. A. Kunkel,James P. Springer,J. Hirshfield +16 more
TL;DR: In this article, 3.3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described.
Journal ArticleDOI
Synthesis and resolution of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones
Mark G. Bock,Robert M. DiPardo,Ben E. Evans,Kenneth E. Rittle,Daniel F. Veber,Roger M. Freidinger,J. Hirshfield,James P. Springer +7 more
Journal ArticleDOI
Design of Nonpeptidal Ligands for a Peptide Receptor: Cholecystokinin Antagonists.
B. E. Evans,Kenneth E. Rittle,Mark G. Bock,Robert M. DiPardo,Roger M. Freidinger,W. L. Whitter,N. P. Gould,G. F. Lundell,Carl F. Homnick,D. F. Veber,P. S. Anderson,R. S. L. Chang,Victor J. Lotti,D. J. Cerino,Tsing-Bau Chen,P. J. King,K. A. Kunkel,J. P. Springer,J. Hirshfield +18 more
TL;DR: Coupling of the benzophenones (I) with D-tryptophan methyl ester hydrochloride (II) gives the benzodiazepinones (III) as mentioned in this paper.