J. Jung

TL;DR: Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization.

TL;DR: It is shown that several supercritical processes have been developed to prepare composite particles of poorly soluble active ingredients, leading to promising results in terms of dissolution rate enhancement.

TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.

TL;DR: The first sections of this review aim at reporting on the evolution of the initiators/catalytic systems and of the synthesis conditions in order to produce aliphatic polyesters with controlled macromolecular parameters by still "greener" ways.

TL;DR: This review focuses on the toolbox of available methods for the preparation of polymeric nanoparticles and highlights some recent examples from the literature that demonstrate the influence of the preparation method on the physicochemical characteristics of the nanoparticles.

TL;DR: Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization.

TL;DR: This review is a comprehensive review specifically focused on the formation of biodegradable particles for drug and gene delivery system using supercritical fluid and dense gas.