J. M. Müller

Bio: J. M. Müller is an academic researcher from Ciba Specialty Chemicals. The author has contributed to research in topics: Rauwolfia alkaloid. The author has an hindex of 5, co-authored 5 publications receiving 269 citations. Previous affiliations of J. M. Müller include University of Basel.

Reserpin, der sedative Wirkstoff ausRauwolfia serpentina Benth

Abstract: The sedative principle ofRauwolfia serpentina Benth. has been isolated in pure crystalline form and its chemistry and pharmacology has been studied.

On the constitution of reserpine.

Abstract: Durch alkalische Hydrolyse wird Reserpin in Reserpinsaure, 3,4,5-Trimethoxybenzoesaure und Methanol gespalten. Das Esteralkaloid liess sich aus diesen Spaltstucken wieder resynthetisieren.

Reserpinin, ein neues Alkaloid ausRauwolfia serpentina Benth

Abstract: Reserpinine, a minor alkaloid ofRauwolfia serpentina Benth. accompanying Reserpine, has been isolated, and its structural formula is proposed.

Triterpene acids from Commiphora glandulosa Schinz.

Abstract: Die Isolierung von funfneuen Triterpensauren (« Commisaure-A bis -E », englisch « commic acid-A to -E ») als Methylester ausCommiphora glandulosa Harz wird beschrieben. Sie wurden als Acetate bzw. als die entsprechenden Alkohole charakterisiert.

[Alkaloids of Rauwolfia ligustrina R. & S. Raugustin, a new reserpine-like alkaloid].

Abstract: Twenty-one alkaloids have been identified from the root ofRauwolfia ligustrina R & S The more important ones are reserpine, pseudoreserpine and raugustine, a new base which is isomer to pseudoreserpine The structure of the latter compound is discussed

Small molecule natural products in the discovery of therapeutic agents: the synthesis connection.

Abstract: Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.

Drugs which block the storage of 5-hydroxytryptamine and related amines

Abstract: In 1955 Shore, Brodie and coworkers (Shore, Silver and Brodie 1955, Pletscher, Shore and Brodie 1955) discovered that reserpine caused a marked decrease in the concentration of 5-hydroxytryptamine (5-HT) in tissues and a concomitant rise in the urinary excretion of the 5-HT metabolite 5-hydroxyindoleacetic acid. The deep physiological significance of this discovery became even more evident when reserpine soon afterwards was found to affect tissue catecholamines in a similar manner, an effect leading to block of adrenergic transmission mechanisms (Carlsson and Hillarp 1956a, Bertler, Carlsson and Rosengren 1956). Since then numerous papers have appeared, in which the effects of Rauwolfia alkaloids and a group of similarly acting benzoquinolizines (Pletscher, Besendorf and Bachtold 1958) have been further analyzed. Particular interest has been focussed on the mechanism of action on the abovementioned amines and on the relationship between this action and the various pharmacological effects of Rauwolfia alkaloids and benzoquinolizines. It is the aim of the present Chapter to review and discuss the pertinent literature dealing with these fundamental problems rather than to review in detail the enormous literature on the pharmacology of these agents.

Myrrh--Commiphora chemistry.

Abstract: Myrrh and opopanax has been used throughout history in incense and as a perfume. Since Bible times it has been used for the treatment of wounds. The first attempts to identify content compounds were almost 100 years ago. In this review we discuss the present state of knowledge in the chemistry of substances of Commiphora spp.