J
J.M. Trent
Researcher at National Institutes of Health
Publications - 59
Citations - 5780
J.M. Trent is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Constitution & Gene. The author has an hindex of 19, co-authored 59 publications receiving 5676 citations. Previous affiliations of J.M. Trent include Translational Genomics Research Institute & Lund University.
Papers
More filters
Journal ArticleDOI
Molecular classification of cutaneous malignant melanoma by gene expression profiling
M. Bittner,Paul S. Meltzer,Yi Chen,Yong-hui Jiang,E. A. Seftor,Mary J.C. Hendrix,Michael D. Radmacher,Richard M. Simon,Zohar Yakhini,Amir Ben-Dor,Amir Ben-Dor,Nick Sampas,Edward R. Dougherty,Ena Wang,Francesco M. Marincola,C. Gooden,John Lueders,Arthur A. Glatfelter,P.C.A. Pollock,John D. Carpten,E. Gillanders,D. Leja,K. Dietrich,Christian Beaudry,Michael E. Berens,David S. Alberts,Vernon K. Sondak,Nicholas K. Hayward,J.M. Trent +28 more
TL;DR: Many genes underlying the classification of this subset of melanomas are differentially regulated in invasive melanomas that form primitive tubular networks in vitro, a feature of some highly aggressive metastatic melanomas.
Journal ArticleDOI
Gene-Expression Profiles in Hereditary Breast Cancer
Ingrid Hedenfalk,David Duggan,Yi Chen,Michael D. Radmacher,M. Bittner,Richard M. Simon,P. Meltzer,Barry A. Gusterson,Manel Esteller,O. P. Kallioniemi,Benjamin S. Wilfond,Åke Borg,J.M. Trent,Mark Raffeld,Zohar Yakhini,Amir Ben-Dor,Edward R. Dougherty,Juha Kononen,Lukas Bubendorf,W Fehrle,Stefania Pittaluga,Sofia Gruvberger,Niklas Loman,Oskar T. Johannsson,Håkan Olsson,Guido Sauter +25 more
TL;DR: Significantly different groups of genes are expressed by breast cancers with BRCA1 mutations and breast cancersWith BRCa2 mutations, the results suggest that a heritable mutation influences the gene-expression profile of the cancer.
Journal ArticleDOI
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome
John D. Carpten,Christiane M. Robbins,Andrea Villablanca,Lars Forsberg,Silvano Presciuttini,Joan E. Bailey-Wilson,William F. Simonds,E. Gillanders,A.M. Kennedy,Jindong Chen,Sunita K. Agarwal,Raman Sood,Mary Pat Jones,Tracy Moses,C. Haven,David Petillo,P.D. Leotlela,Brian Harding,David Cameron,Anna A.J. Pannett,Anders Höög,H. Heath,Laura James-Newton,Bruce G. Robinson,R.J. Zarbo,Branca M. Cavaco,Wassif S. Wassif,N.D. Perrier,I.B. Rosen,Ulf Kristoffersson,Peter D. Turnpenny,Lars-Ove Farnebo,G. M. Besser,Charles E. Jackson,Hans Morreau,J.M. Trent,Rajesh V. Thakker,Stephen J. Marx,Bin Tean Teh,Catharina Larsson,Maurine R. Hobbs +40 more
TL;DR: The findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT–JT and in development of some sporadic parathyroid tumors.
Journal ArticleDOI
Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.
Mieke Schutte,L T da Costa,Stephan A. Hahn,Christopher A. Moskaluk,Hoque At,Ester Rozenblum,C. L. Weinstein,M. Bittner,Paul S. Meltzer,J.M. Trent +9 more
TL;DR: Two DNA fragments that identified a homozygous deletion in a human pancreatic adenocarcinoma, mapping to a 1-centimorgan region at chromosome 13q12.3 suggests that the same gene may be involved in multiple tumor types and that its function is that of a tumor suppressor rather than that of an dominant oncogene.
Journal ArticleDOI
Nuclear architecture and the induction of chromosomal aberrations
Christoph Cremer,Christian Münkel,Martin Granzow,Anna Jauch,Steffen Dietzel,Roland Eils,Xin Yuan Guan,Paul S. Meltzer,J.M. Trent,Jörg Langowski,Thomas Cremer,Thomas Cremer +11 more
TL;DR: The present state of knowledge of the territorial organization of interphase chromosomes and their topological relationships with other macromolecular domains in the human cell nucleus is summarized, and data from computer simulations of chromosome territory distributions are presented.