J. Michael Kilby

TL;DR: The detection of autologous Nab as early as 52 days after detection of HIV-specific antibodies is reported, indicating a new mechanism contributing to HIV-1 persistence in the face of an evolving antibody repertoire.

TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.

TL;DR: These findings provide the first evidence for the rapid emergence of clinical resistance to a novel class of HIV-1 entry inhibitors and may be relevant to future treatment strategies involving these agents.

TL;DR: In this paper, the authors analyzed blood and lymph node tissues obtained concurrently from HIV-infected patients before and after initiation of HAART and found that activated T cells were significantly more frequent in lymph node tissue compared with blood at both time points.

TL;DR: The way in which HIV-1 enters cells and potential means of denying the virus admission to cells are reviewed.