J
J. Michael McIntosh
Researcher at University of Utah
Publications - 288
Citations - 16821
J. Michael McIntosh is an academic researcher from University of Utah. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine receptor. The author has an hindex of 67, co-authored 280 publications receiving 15528 citations. Previous affiliations of J. Michael McIntosh include University of Colorado Boulder & University of Colorado Denver.
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Journal ArticleDOI
The odyssey of marine pharmaceuticals: a current pipeline perspective
Alejandro M. S. Mayer,Keith B. Glaser,Carmen Cuevas,Robert S. Jacobs,William R. Kem,R. Daniel Little,J. Michael McIntosh,David J. Newman,Barbara C. M. Potts,Dale E. Shuster +9 more
TL;DR: From a global perspective the marine pharmaceutical pipeline remains very active, and now has sufficient momentum to deliver several additional compounds to the marketplace in the near future; this review provides a current view of the pipeline.
Journal ArticleDOI
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice
Nicolas Champtiaux,Cecilia Gotti,Matilde Cordero-Erausquin,Denis J. David,Cédric Przybylski,Clément Léna,Francesco Clementi,Milena Moretti,Francesco M. Rossi,Nicolas Le Novère,J. Michael McIntosh,Alain M. Gardier,Jean-Pierre Changeux +12 more
TL;DR: It is established that α6β2* nAChRs are functional and sensitive to α-conotoxin MII inhibition, and somato-dendritic (nonα6)α4β2- nA ChRs most likely contribute to nicotine reinforcement.
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A new conus peptide ligand for mammalian presynaptic Ca2+ channels
David R. Hillyard,Virginia D. Monje,Isabelle M. Mintz,Bruce P. Bean,Laszlo Nadasdi,J. Ramachandran,George P. Miljanich,Aryan Azimi-Zoonooz,J. Michael McIntosh,Lourdes J. Cruz,Lourdes J. Cruz,Julita S. Imperial,Baldomero M. Olivera +12 more
TL;DR: A new Conus peptide is described that is an effective inhibitor of omega-CgTx-GVIA-resistant synaptic transmission and defines a general approach for obtaining ligands with novel receptor subtype specificity from Conus.
Journal ArticleDOI
A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors
G. Edward Cartier,Doju Yoshikami,William R. Gray,Siqin Luo,Baldomero M. Olivera,J. Michael McIntosh +5 more
TL;DR: A 16-amino acid peptide from the venom of the marine snail Conus magus was identified by electrophysiologically screening venom fractions against cloned nicotinic receptors expressed in Xenopus oocytes.
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Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.
Outi Salminen,Karen L. Murphy,Karen L. Murphy,J. Michael McIntosh,John Drago,Michael J. Marks,Allan C. Collins,Sharon R. Grady +7 more
TL;DR: Both the transient and persistent phases of nicotine-stimulated dopamine release were partially inhibited by alpha-CtxMII with equal potency, and the subunit composition of functional nAChRs, was assessed in mice with null mutations for individual nA ChRs.