Author
J. Ph. Devissaguet
Bio: J. Ph. Devissaguet is an academic researcher from University of Paris. The author has contributed to research in topics: Nanocapsules & Interfacial polymerization. The author has an hindex of 4, co-authored 4 publications receiving 2128 citations.
Papers
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TL;DR: In this paper, an attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).
2,017 citations
TL;DR: In this paper, the dispersion of an alcoholic solution of isobutylcyanoacrylate and oil in water, by interfacial polymerization, allows the formation of nanocapsules with an average diameter of about 200-300 nm.
241 citations
TL;DR: Intravenously injected primaquine-loaded nanoparticles were well tolerated by healthy and Leishmania donovani-infected mice and the 50% lethal dose of primaquined nanoparticles was significantly reduced when compared to that of free Primaquine.
64 citations
01 Jan 1990
TL;DR: The fate of a drug after administration in vivo is determined by a combination of several processes: distribution and elimination when given intravenously and absorption, distribution and Elimination when an extravascular route is used.
Abstract: The fate of a drug after administration in vivo is determined by a combination of several processes: distribution and elimination when given intravenously and absorption, distribution and elimination when an extravascular route is used. Regardless of the mechanisms involved, each of these processes depends mainly on the physico-chemical properties of the drug and therefore, for the most part, on its chemical structure.
4 citations
Cited by
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TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
3,284 citations
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
3,116 citations
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years.
3,070 citations
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
2,786 citations
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
2,753 citations