J. R. Harris

Bio: J. R. Harris is an academic researcher. The author has contributed to research in topics: Apolipoprotein E & Endosome. The author has an hindex of 5, co-authored 5 publications receiving 112 citations.

Protein aggregation and fibrillogenesis in cerebral and systemic amyloid disease

Abstract: I. Introduction 1. Introduction and Technical Survey J. Robin Harris and Nathaniel G. Milton II. Basic Science 2. Fibril Formation by Short Synthetic Peptides Andrew Smith 3. In vitro Oligomerization and Fibrillogenesis of Amyloid-beta Peptides Nuria Benseny-Cases, Oksana Klementieva and Josep Cladera 4. Tau Fibrillogenesis Nitin Chaudhary and Ramakrishnan Nagaraj 5. Prion protein Aggregation and Fibrillogenesis In vitro Jan Stohr 6. alpha-Synuclein Aggregation and Modulating Factors Katerina E. Paleologou and Omar M. A. El-Agnaf 7. Pathological Self-aggregation of beta2-microglobulin: A Challenge for Protein Biophysics Gennaro Esposito, Alessandra Corazza, and Vittorio Bellotti 8. Islet amyloid polypeptide - Aggregation and fibrillogenesis in vitro and its Inhibition Janine Seeliger and Roland Winter 9. Mechanisms of Transthyretin Aggregation and Toxicity Robert J. Gasperini, David W. Klaver, Xu Hou, Marie-Isabel Aguilar and David H. Small 10. Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev and Sorin Luca 11. Aggregation and Fibrillogenesis of Proteins not Associated with Disease - A few Case Studies Moritz Lasse, Juliet A. Gerrard and F. Grant Pearce 12. Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs Alagiri Srinivasan 13. Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Abeta) and other disease-related peptides/proteins by plant extracts and herbal compounds Suresh Kumar, Edward Okello and J. Robin Harris III. Clinical Science: The Cerebral and Systemic Amyloid Diseases Pathogenesis and therapeutic consideration of the major disorders 14. Alzheimer's Disease Vanessa J. De-Paula, Marcia Radanovic, Breno S. Diniz, Orestes V. Forlenza 15. Modeling the Polyglutamine Aggregation Pathway in Huntington's Disease: from Basic Studies to Clinical Applications Keizo Sugaya 16. Parkinson's Disease Timothy R. Mhyre, James T. Boyd, Robert W. Hamill, and Kathleen Maguire-Zeiss 17. Human Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Diseasae Beata Sikorska and Pawel P. Liberski 18. Animal Prion Diseases Otto Windl and Mike Dawson 19. beta2-microglobulin Amyloidosis Dorthe B. Corlin and Niels H.H. Heegaard 20. Systemic AA Amyloidosis Jennifer H Pinney and Helen J Lachmann 21. Familial Amyloidotic Polyneuropathy and Transthyretin Takamura Nagasaka 22. The Challenge of Systemic Immunoglobulin Light-chain Amyloidosis (AL) Giovanni Palladini and Raymond L Comenzo

Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins

Abstract: This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles). Featuring 20 chapters addressing invertebrate and vertebrate respiratory proteins, lipoproteins and other body fluid proteins, and drawing on the editors' extensive research in the field, it is a valuable addition to the Subcellular Biochemistry book series. The book covers a wide range of topics, including lipoprotein structure and lipid transport; diverse annelid, crustacean and insect defense proteins; and insect and vertebrate immune complexes. It also discusses a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein. Given its scope, the book appeals to biologists, biomedical scientists and clinicians, as well as advanced undergraduates and postgraduates in these disciplines. Available as a printed book and also as an e-book and e-chapters, the fascinating material included is easily accessible.

Alzheimer's disease: cellular and molecular aspects of amyloid β

Abstract: 1. The Contribution of Microscopy to the Study of Amyloid Plaques and to Amyloid-ss Fibrillogenesis J. ROBIN HARRIS 2. Transgenic Mouse Models for APP Processing and Alzheimer's Disease: Early and Late Defects Tom Van Dooren, Ilse Dewachter, Peter Borghgraef and Fred Van Leuven 3. Oxidative stress in Alzheimer's Disease: Implications for Prevention and Therapy CHRISTIAN BEHL 4. ss-Secretase, APP and Ass in Alzheimer's Disease ROBERT VASSAR 5. The Non-Amyloidogenic Pathway: Structure and Function of a-Secretases Elzbieta Kojro and Falk Fahrenholz 6. Amyloid ss Degradation: A Challenging Task for Brain Peptidases Laura Morelli, Ayelen Bulloj, Maria Celeste Leal and Eduardo M. Castano 7. The Protective Role of Vitamin E in Vascular Amyloid ss-Mediated Damage Francisco Jose Munoz, Montserrat Sole and Mireia Coma 8. Amyloid Accumulation and Pathogensis of Alzheimer's Disease: Significance of Monomeric, Oligomeric and Fibrillar Ass Charles C. Glabe 9. Cholesterol and Amyloid ss Fibrillogenesis Katsuhiko Yanagisawa 10. Alzheimer's b-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding Hideyo Inouye and Daniel A. Kirschner 11. The Aluminium-Amyloid Cascade Hypothesis and Alzheimer's Disease CHRISTOPHER EXLEY 12. Amyloid-ss Metal Interaction and Metal Chelation Math P. Cuajungco, Christopher, J. Frederickson and Ashley I. Bush 13. The Interaction of Amyloid-ss with ApoE Donald B. Carter 14. Clusterin and Alzheimer's Disease Miguel Calero, Agueda Rostagno, Blas Frangione and Jorge Ghiso 15. Acetylcholinesterase Interaction with Alzheimer Amyloid ss Nibaldo C. Inestrosa, Juan Paulo Sagaland Marcela Colombres 16. Membrane Disordering Effects of ss-Amyloid Peptides Gunter P. Eckert, W.G. Wood and Werner E. Muller 17. The Role of Alzheimer Ass Peptides in Ion Transport Across Cell Membranes Vernon M. Ingram 18. Amyloid Inhibitors and ss-Sheet Breakers Claudio Soto and Lisbell Estrada 19. Cholesterol and Alzheimer's Disease: Statins, Cholesterol Depletion in APP Processing and Ass Generation Tobias Hartmann 20. Phosphorylated Amyloid-ss: The Toxic Intermediate in Alzheimer's Disease Neurodegeneration NATHANIEL G. N. MILTON Index

Cholesterol binding and cholesterol transport proteins : structure and function in health and disease

Abstract: Cholesterol-Protein Interaction: Methods and Cholesterol Reporter Molecules.- Cholesterol in Alzheimer's Disease and other Amyloidogenic Disorders.- Cholesterol-Binding Viral Proteins in Virus Entry and Morphogenesis.- Sterol-Protein Interactions in Cholesterol and Bile Acid Synthesis.- Cholesterol Oxidase: Structure and Function.- Oxysterol-Binding Proteins.- High Density Lipoprotein Structure-Function and Role in Reverse Cholesterol Transport.- Lipoprotein Modification and Macrophage Uptake: Role of Pathologic Cholesterol Transport in Atherogenesis.- Cholesterol Interaction with Proteins That Partition into Membrane Domains: An Overview.- Caveolin, Sterol Carrier Protein-2, Membrane Cholesterol-Rich Microdomains and Intracellular Cholesterol Trafficking.- Cholesterol in Niemann-Pick Type C disease.- Protein Mediators of Sterol Transport Across Intestinal Brush Border Membrane.- Cholesterol at the Endoplasmic Reticulum: Roles of the Sigma-1 Receptor Chaperone and Implications thereof in Human Diseases.- Prominin-1: A Distinct Cholesterol-Binding Membrane Protein and the Organisation of the Apical Plasma Membrane of Epithelial Cells.- Mammalian StAR-Related Lipid Transfer (START) Domains with Specificity for Cholesterol: Structural Conservation and Mechanism of Reversible Binding.- Membrane Cholesterol in the Function and Organization of G-Protein Coupled Receptors.- Cholesterol Effects on Nicotinic Acetylcholine Receptor: Cellular Aspects.- Cholesterol and Myelin Biogenesis.- Cholesterol and Ion Channels.- The Cholesterol-Dependent Cytolysin Family of Gram-Positive Bacterial Toxins.- Cholesterol Specificity of Some Heptameric ?-Barrel Pore-Forming Bacterial Toxins: Structural and Functional Aspects.- Cholesterol-Binding Toxins and Anti-cholesterol Antibodies as Structural Probes for Cholesterol Localization.

Endocytic Components: Identification and Characterization

Abstract: Toward a Biochemical Definition of the Endosomal Compartment S.L. Schmid Analytical Subcellular Fractionation of Endosomal Compartments in Rat Hepatocytes P.J. Courtoy Reconstitution of Endosomal Transport and Proteolysis J.S. Blum, et al. Quantitative Fluorescence Techniques for the Characterization of Endocytosis in Intact Cells N.H. Salzman, F.R. Maxfield Endocytosis and Function of the Hepatic Asialoglycoprotein Receptor P.H. Weigel Characterization of Endocytic Components of Liver Nonparenchymal Cells R. Wattiaux, et al. The Endocytic Compartments of Normal and Regenerating Liver C. Enrich, W.H. Evans Potential Role of Endosomes in Transmembrane Signalling M.N. Khan, et al. Index.

Raman spectroscopy of lipids: a review

Abstract: Raman spectra of 35 lipids are presented and analyzed in this work. Selected compounds, i.e. saturated/unsaturated fatty acids, triacylglycerols, cholesterol, cholesteryl esters and phospholipids, were chosen to review key lipids involved in cardiovascular disease development. Differences in Raman signatures both between diverse groups of lipids as well as various members of the same family are investigated in detail in order to elucidate marker features enabling detection and discrimination of lipids in complex samples, particularly of biological origin. This work complements our previous review on important biomolecules, i.e. proteins, and presents a comprehensive database of Raman spectra of naturally occurring lipids. Copyright © 2014 John Wiley & Sons, Ltd.

Advances in experimental medicine and biology

Abstract: Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. The series also provides scientists with up to date information on emerging topics and techniques. 2015 Impact Factor: 1.953

ANS binding reveals common features of cytotoxic amyloid species

Abstract: Oligomeric assemblies formed from a variety of disease-associated peptides and proteins have been strongly associated with toxicity in many neurodegenerative conditions, such as Alzheimer’s disease. The precise nature of the toxic agents, however, remains still to be established. We show that prefibrillar aggregates of E22G (arctic) variant of the Aβ1−42 peptide bind strongly to 1-anilinonaphthalene 8-sulfonate and that changes in this property correlate significantly with changes in its cytotoxicity. Moreover, we show that this phenomenon is common to other amyloid systems, such as wild-type Aβ1–42, the I59T variant of human lysozyme and an SH3 domain. These findings are consistent with a model in which the exposure of hydrophobic surfaces as a result of the aggregation of misfolded species is a crucial and common feature of these pathogenic species.

Introduction To Protein Structure

Abstract: Thank you for downloading introduction to protein structure. As you may know, people have look numerous times for their chosen books like this introduction to protein structure, but end up in infectious downloads. Rather than enjoying a good book with a cup of tea in the afternoon, instead they cope with some malicious virus inside their laptop. introduction to protein structure is available in our book collection an online access to it is set as public so you can get it instantly. Our books collection saves in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the introduction to protein structure is universally compatible with any devices to read.