J. Stuart

Bio: J. Stuart is an academic researcher from University of Iowa. The author has contributed to research in topics: Gene & Control of chromosome duplication. The author has an hindex of 1, co-authored 1 publications receiving 91 citations.

A new host gene (groPC) necessary for lambda DNA replication.

Abstract: The isolation of a bacterial mutation in a gene, designated groPC, which affects the growth of phages lambda and P2 is described. Lambda replication is severely limited in the strain, and some lambda π mutations, which map in (or near) the P gene, allow growth. The gro mutation, groPC259, is recessive to wild type and maps between threonine (thr) and diaminopimelate (dapB) on the E. coli chromosome. The possibility that the groPC gene is concerned with host DNA replication is discussed.

The heat shock response.

Abstract: The response of cells to a heat shock or other stresses is the activation of a small number of genes which were previously inactive or transcribed at low levels. This response has been observed in a wide variety of bacterial, plant, and animal species. Evidence is accumulating that at least some of the proteins found in diverse species are similar, indicating a conservation of the response and the proteins in evolution. In a number of organisms a strong positive correlation has been found between the presence of heat shock proteins and ability of the organism to withstand thermal stress. This review attempts to assess the available data concerning the homology of proteins in different species, the localization of the proteins in cells, and the relationship between heat shock proteins and thermoresistance.

Heat Shock Proteins and Immune Response

Abstract: List of Contents.- Basic Features of Heat Shock Proteins.- Heat Shock Proteins hsp60 and hsp70: Their Roles in Folding, Assembly, and Membrane Translocation of Proteins.- Response of Mammalian Cells to Metabolic Stress Changes in Cell Physiology and Structure/Function of Stress Proteins.- Heat Shock Protein Genes and the Major Histocompatibility Complex.- Heat Shock Protein Functions Related to Immunity.- BiP-A Heat Shock Protein Involved in. Immunoglobulin Chain Assembly.- A Role for Heat Shock Proteins in Antigen Processing and Presentation.- Heat Shock Proteins and Inflammation.- Heat Shock Proteins as Antigens.- Stress-Induced Proteins in Immune Response to Cancer.- Heat Shock Proteins as Virulence Factors of Pathogens.- Heat Shock Proteins as Antigens of Bacterial and Parasitic Pathogens.- Stress Proteins, Autoimmunity, and Autoimmune Disease.- Gamma/Delta T Lymphocytes and Heat Shock Proteins.