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Ja Seong Bae

Bio: Ja Seong Bae is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Thyroid cancer & Thyroidectomy. The author has an hindex of 23, co-authored 88 publications receiving 1426 citations. Previous affiliations of Ja Seong Bae include Catholic University College, Kensington & The Catholic University of America.


Papers
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Journal ArticleDOI
TL;DR: The findings suggest that non-invasive follicular thyroid neoplasm with papillary-like nuclear features should not be regarded as a benign thyroidNeoplasm as it can present with lymph node micrometastasis and should not been diagnosed in the presence of even a single papillary structure.

155 citations

Journal ArticleDOI
TL;DR: The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy.
Abstract: Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Two hundred eighty five patients (8.4%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2% (22/99) and the cancer risks associated with focal and diffuse FDG uptake were 30.9% and 6.4%. There was a significant difference in the SUVmax between the benign and malignant nodules (3.35 ± 1.69 vs. 6.64 ± 4.12; P < 0.001). There was a significant correlation between the SUVmax and the size of the cancer. The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.

110 citations

Journal ArticleDOI
TL;DR: In this paper, the prognostic value of p53 in the outcome of adjuvant anthracycline-containing chemotherapy was evaluated according to molecular subclasses defined using the expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2.
Abstract: OBJECTIVE A recent suggestion is that the predictive value of a single biomarker may rely on the genetic background on the tumor and that different breast cancer subgroups may have different predictive markers of response to chemotherapy. The prognostic value of p53 in the outcome of adjuvant anthracycline-containing chemotherapy was evaluated according to molecular subclasses defined using the expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. METHODS Subjects were patients (n = 135) with invasive ductal carcinoma treated with adjuvant anthracycline-based chemotherapy between 1994 and 2000 in our hospital. Clinico-pathological features were reviewed by retrospective examination of medical records. RESULTS Overall survival rate was not independently predictive by p53 status (P = 0.182). However, in triple-negative cases, there was statistically significant survival difference (P = 0.034) and no statistically significant difference (P = 0.783) in non-triple-negative cases by p53 status. In the Cox proportional hazard analysis, p53 was also strongly predictive for relapse-free survival (P = 0.013) and overall survival (P = 0.049) in triple-negative patients. CONCLUSIONS p53 status could be a specific prognostic factor in triple-negative breast cancer patients treated by adjuvant anthracycline-based regimen. When p53 is positive in triple-negative breast cancer, we could expect poor survival, prompting aggressive or alternative treatment.

77 citations

Journal ArticleDOI
TL;DR: It is not clear that the BRAF(V600E) mutation is useful for prediction of poor prognosis of PTC, but a high-risk Metastasis, Patient Age, Completeness of resection, local Invasion and Tumor Size and lymph node metastasis were not significantly associated with the BRAFs.
Abstract: Objective Recent studies have shown that a BRAF V600E reflects poor prognosis, mainly in Western countries. However, some clinicians in Japan have suggested that the BRAF V600E mutation is not associated with a poor prognosis. Therefore, we investigated a relationship between BRAF V600E mutation and clinicopathologic factors. Methods From September 2008 to December 2009, we performed routine analysis of the BRAF V600E mutation using thyroid cancer tissue from 424 patients who underwent thyroidectomy with cervical lymph node dissection. Results The BRAF V600E mutation was found in 335 of 424 cases (79%) and was higher in classic papillary thyroid carcinoma (PTC) (79.7%) than in the follicular variant of PTC (62.5%) ( P = .019). On univariate analysis, the BRAF V600E mutation was associated with extrathyroidal extension ( P = .009) and variants of PTC ( P = .019), but a high-risk Metastasis, Patient Age, Completeness of resection, local Invasion and Tumor Size (MACIS) score (≥ 6) ( P = .146) and lymph node metastasis ( P = .628) were not significantly associated with the BRAF V600E mutation. Multivariate analysis showed that extrathyroidal extension is independently associated with the BRAF V600E mutation (relative ratio: 2.466; 95% confidence interval, 1.213–5.011; P Conclusion It is not clear that the BRAF V600E mutation is useful for prediction of poor prognosis of PTC.

69 citations

Journal ArticleDOI
06 Nov 2013-Thyroid
TL;DR: Thyroid FNAC has a low sensitivity for the detection of FVPTC regardless of histologic subtype, and RAS mutational analysis is more useful than BRAF testing to improve the triage efficacy of FNAC for FVP TC.
Abstract: Background: The follicular variant of papillary thyroid carcinoma (FVPTC) presents distinct histologic subtypes and molecular genotyping. The preoperative diagnosis of FVPTC through fine-needle aspiration cytology (FNAC) is challenging. Methods: We reviewed 59 archival thyroid FNAC specimens of surgically confirmed FVPTC according to histologic subtype: encapsulated FVPTC (n=30) and infiltrative FVPTC (n=29). Galectin-3 immunostaining and molecular analyses for BRAF and three RAS genes (NRAS, HRAS, and KRAS) were performed. Results: FNAC diagnoses of FVPTC included benign (5%), atypia of undetermined significance (19%), follicular neoplasm/suspicious for follicular neoplasm (14%), suspicious for PTC (29%), and PTC (34%). Galectin-3 immunostaining was positive in 50% of FNAC specimens. A BRAF mutation was found only in 14 (24%) tumors with the FNAC diagnosis of PTC or suspicious for PTC: 13 cases with the usual c.1799T>A (p.V600E) mutation and 1 case with a 3 base-pair deletion (c.1799_1801delTGA), resulti...

67 citations


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01 Nov 2009-Thyroid
TL;DR: Evidence-based recommendations are developed to inform clinical decision-making in the management of thyroid nodules and differentiated thyroid cancer and represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Abstract: Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer. Methods: The specific clinical questions addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of task force members. Task force panel members were educated on knowledge synthesis methods, including electronic database searching, review and selection of relevant citations, and critical appraisal of selected studies. Published English language articles on adults were eligible for inclusion. The American College of Physicians Guideline Gr...

10,501 citations

01 Jan 2014
TL;DR: The Bethesda System for Reporting Thyroid Cytopathology represents a reliable and valid reporting system for thyroid cytology and will have effect in transforming, unifying, and improving the reporting of thyroid FNA results.
Abstract: Background - FNAC has become the most prominent, and the easiest way, to morphologically evaluate lesions of the thyroid and may be the procedure of choice in the preoperative evaluation of thyroid nodules. In the past, ambiguous and inconsistent diagnostic criteria and terminology have hampered sample interpretation and patient management. The TBSRTC will have effect in transforming, unifying, and improving the reporting of thyroid FNA results Aims – The aim of our study to evolve uniform reporting system for thyroid cytopathology, facilitate effective cytological & histological correlation, reduce the unnecessary surgical management of thyroid lesions, which can easily be treated medically. Materials and Methods – FNAC was performed on two hundred patients diagnosed with thyroid lesion during a period of two years (2010-2012). The smears were prepared, stained by May-Grunewald-Giemsa stain and reported according to Bethesda system reporting of thyroid lesions. The cytological diagnosis was compared with histopathological diagnosis, wherever possible to find out the diagnostic accuracy. Results - The statistical analysis in the present study revealed sensitivity of 95.24 percent, specificity of 78.72 percent, positive predictive value of 66.66 percent, negative predictive value of 97.37 percent and diagnostic accuracy of 83.82 percent. Sensitivity and specificity of pre-Bethesda reporting system was 75 percent and 97.95 percent respectively. Positive predictive value was 85.71 percent, negative predictive value was 95.92 percent and diagnostic accuracy was 94.64 percent. Conclusion - After analyzing the results of the present study, it was concluded that the Bethesda System for Reporting Thyroid Cytopathology represents a reliable and valid reporting system for thyroid cytology.

475 citations

Journal ArticleDOI
TL;DR: The revised guideline for the optimal use of radiofrequency ablation for thyroid tumors is based on a comprehensive analysis of the current literature and expert consensus.
Abstract: Thermal ablation using radiofrequency is a new, minimally invasive modality employed as an alternative to surgery in patients with benign thyroid nodules and recurrent thyroid cancers. The Task Force Committee of the Korean Society of Thyroid Radiology (KSThR) developed recommendations for the optimal use of radiofrequency ablation for thyroid tumors in 2012. As new meaningful evidences have accumulated, KSThR decided to revise the guidelines. The revised guideline is based on a comprehensive analysis of the current literature and expert consensus.

340 citations

Journal ArticleDOI
TL;DR: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) was performed as safely as OT, requires only conventional laparoscopic instruments, and avoids incisional scars; thus, the approach may be an option for select patients.
Abstract: Importance Natural orifice transluminal endoscopic surgery thyroidectomy is a novel approach to avoid surgical scars. Objective To compare the safety and outcomes of the transoral endoscopic thyroidectomy vestibular approach (TOETVA) with those of open thyroidectomy (OT). Design, Setting, and Participants This study retrospectively reviewed all TOETVA and OT operations performed from April 1, 2014, through August 31, 2016, at Police General Hospital, Bangkok, Thailand. All patients who underwent TOETVA and patients who underwent OT were included. Exclusion criteria were (1) previous neck surgery, (2) substernal goiter, (3) lymph node or distance metastasis, and (4) suspicious invasion to the adjacent organs. Propensity score matching was conducted to reduce selective bias. Main Outcomes and Measures Operative time, blood loss, and complications related to thyroid surgery. Results Of the 425 patients who underwent transoral endoscopic thyroidectomy (mean age, 35.3 [12.1] years; age range, 16-81 years; 389 [92.2%] female), 422 successfully were treated with the TOETVA; 3 patients were converted to a conventional operation because of bleeding. Twenty-five patients (5.9%) had transient recurrent laryngeal nerve palsy, and 46 (10.9%) had transient hypoparathyroidism. None had permanent recurrent laryngeal nerve palsy or permanent hypoparathyroidism. Three patients (0.7%) had transient mental nerve injury; all cases resolved by 4 months. One patient developed postoperative hematoma treated by OT. Twenty patients (4.7%) had seroma treated by simple aspiration. Operative time was longer for the TOETVA compared with the OT group (100.8 [39.7] vs 79.4 [32.1] minutes,P = 1.61 × 10−10). The mean (SD) visual analog scale score for pain was lower in the TOETVA group (1.1 [1.2] vs 2.8 [1.2],P = 2.52 × 10−38). Estimated mean (SD) blood loss (36.9 [32.4] vs 37.6 [23.1] mL,P = .43) and rate of complications (45 of 216 [20.8%] vs 38 of 216 [17.6%],P = .41) were not significantly different in the TOETVA vs OT group. Conclusions and Relevance The TOETVA was performed as safely as OT, requires only conventional laparoscopic instruments, and avoids incisional scars; thus, the approach may be an option for select patients.

320 citations