J
Jacinta Lucero
Researcher at Salk Institute for Biological Studies
Publications - 51
Citations - 6686
Jacinta Lucero is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Chromatin & Epigenetics. The author has an hindex of 27, co-authored 45 publications receiving 4974 citations. Previous affiliations of Jacinta Lucero include University of California, San Diego & Scripps Research Institute.
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Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
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Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
M. Margarita Behrens,Sameh S. Ali,Diep N. Dao,Jacinta Lucero,Grigoriy Shekhtman,Kevin L. Quick,Laura L. Dugan +6 more
TL;DR: It is shown that exposure of mice to ketamine induced a persistent increase in brain superoxide due to activation in neurons of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which suggests that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis.
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Matrix Metalloproteinases Increase Very Early During Experimental Focal Cerebral Ischemia
TL;DR: Findings highlight the early potential role of MMP-2 in the degradation of basal lamina leading to neuronal injury, and an association of M MP-9 with hemorrhagic transformation after focal cerebral ischemia, which is highly correlated with the extent of neuron injury and the number of injured neurons.
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Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex
Chongyuan Luo,Christopher L. Keown,Laurie Kurihara,Jingtian Zhou,Jingtian Zhou,Yupeng He,Yupeng He,Jun-Hao Li,Rosa Castanon,Jacinta Lucero,Joseph R. Nery,Justin P. Sandoval,Brian Bui,Terrence J. Sejnowski,Terrence J. Sejnowski,Timothy T. Harkins,Eran A. Mukamel,M. Margarita Behrens,Joseph R. Ecker +18 more
TL;DR: A comprehensive map of methylation variation in neuronal cell populations, including a between-species comparison, illustrates how epigenetic diversity plays important roles in neuronal development.
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Transgenic mice with a reduced core body temperature have an increased life span
Bruno Conti,Manuel Sanchez-Alavez,Raphaelle Winsky-Sommerer,Maria C. Morale,Jacinta Lucero,Sara E. Brownell,Véronique Fabre,Salvador Huitron-Resendiz,Steven J. Henriksen,Eric P. Zorrilla,Luis de Lecea,Tamas Bartfai +11 more
TL;DR: It is reported that transgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic temperature, and modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR.